Genome Stability

From Virus to Human Application Volume 26
Herausgeber: Kovalchuk, Igor; Kovalchuk, Olga

• Broschiertes Buch

Produktbeschreibung

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

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Produktdetails

• Verlag: Elsevier Science
• 2nd edition
• Seitenzahl: 760
• Erscheinungstermin: 22. Juli 2021
• Englisch
• Abmessung: 273mm x 218mm x 35mm
• Gewicht: 2088g
• ISBN-13: 9780323856799
• ISBN-10: 0323856799
• Artikelnr.: 60979200

Inhaltsangabe

1. Genome stability: An evolutionary perspective
Part I Genome instability of viruses 2. Genetic instability of RNA viruses
3. Genome instability in DNA viruses
Part II Genome instability in bacteria and archaea 4. Genome instability in
bacteria and archaea: Strategies for maintaining genome stability 5. Genome
instability in bacteria: Causes and consequences 6. CRISPR - Bacterial
immune system
Part III Genome stability of unicellular eukaryotes 7. From micronucleus to
macronucleus: Programmed DNA rearrangement in ciliates is regulated by
non-coding RNA molecules 8. Homologous recombination and nonhomologous
end-joining repair in yeast
Part IV Genome stability in multicellular eukaryotes 9. Meiotic and mitotic
recombination: First in flies 10. Genome stability in Drosophila: Mismatch
repair and genome stability 11. Genome stability in Caenorhabditis elegans
12. Plant genome stability-General mechanisms 13. Genetic engineering in
plants using CRISPRs
Part V Genome stability in mammals 14. Cell cycle control and DNA-damage
signaling in mammals 15. The role of p53/p21/p16 in DNA damage signaling
and DNA repair 16. Roles of RAD18 in DNA replication and post-replication
repair (PRR) 17. Base excision repair and nucleotide excision repair 18.
DNA mismatch repair in mammals 19. Repair of double-strand breaks by
nonhomologous end joining; Its components and their function 20. Homologous
recombination in mammalian cells: From molecular mechanisms to pathology
21. Telomere maintenance and genome stability 22. Chromatin, nuclear
organization and genome stability in mammals 23. Role of DNA mthylation in
genome stability 24. Non-coding RNAs in genome integrity
Part VI Human diseases associated with genome instability 25. Human
diseases associated with genome instability 26. Cancer and genomic
instability 27. Epigenetic regulation of the cell cycle & DNA-repair in
cancer 28. Genomic instability and aging: Causes and consequences 29. The
DNA damage response and neurodegeneration: Highlighting the role of the
nucleolus in genome (in)stability
Part VII Effect of environment on genome stability 30. Diet and nutrition
31. Chemical carcinogens and their effect on genome and epigenome stability
32. Modern sources of environmental ionizing radiation exposure and
associated health consequences
Part VIII Bystander and transgenerational effects: Epigenetic perspective
33. Sins of fathers through a scientific lens: Transgenerational effects
34. Radiation and chemical induced genomic instability as a driver for
environmental evolution 35. Transgenerational genome instability in plants
36. Methods for the detection of DNA damage 37. Conserved and divergent
features of DNA repair. Future perspectives in genome stability research
38. Off-target effects in genome editing