Anton G. Kutikhin, Arseniy E. Yuzhalin

Genomics of Pattern Recognition Receptors

Applications in Oncology and Cardiovascular Diseases

• Gebundenes Buch

Produktbeschreibung

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Produktdetails

• Verlag: Springer / Springer Basel / Springer, Basel
• Artikelnr. des Verlages: 86277249, 978-3-0348-0687-9
• 2013
• Seitenzahl: 200
• Erscheinungstermin: 10. September 2013
• Englisch
• Abmessung: 241mm x 160mm x 17mm
• Gewicht: 414g
• ISBN-13: 9783034806879
• ISBN-10: 3034806876
• Artikelnr.: 38464177

Inhaltsangabe

The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation.- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword.- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer.- Structural Genomic Variation in Other Toll-like Receptors and Cancer.- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer.- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer.- Structural Genomic Variation in NOD-Like Receptors and Cancer.- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases.- Hot Spots In the Field: Where Should We Go.

Rezensionen

From the reviews:

"This book comprehensively covers the polymorphism of genes-encoding pattern recognition receptors (PRRs) ... . The book is intended for immunologists, cancer researchers, cardiologists, epidemiologists, microbiologists, and geneticists, as well as PhD, graduate, and undergraduate students of biomedical faculties and their lecturers. This is a unique book that analyzes the field of PRR genomics and its practical applications. ... This book will be quite useful for a very wide audience." (Omer Iqbal, Doody's Book Reviews, March, 2014)