Nuweiba area is subjected to severe geo-environmental hazards including flash flood and landslides. Water, rock and mineral resources represent essential wealth for local inhabitants. Hence, this study aims to define the natural resources and geo-environmental hazards in Nuweiba area. Geological, geomorphological, climatological, and hydrological studies have been considered as significant tasks for that purpose. Flash flood risk has been evaluated based on the spatial integration between the morphometric, and Synthetic Conservation Services (SCS). Locations of landslide hazards are defined based on weightage analysis of multi-criteria including distance to earthquakes, slope, aspect, distance to fault, lineaments density, lithology, distance to drainage, drainage density, and land use. The groundwater potential zones are delineated using different types of data comprising SAR, GPR, SRTM, SPOT5, and geologic and topographic maps.El-Zalaga are the most risky wadis. In addition, porphyry copper potential zones are defined based on the mapping of hydrothermal alteration zones and Analytical Hierarchy Process (AHP).