Emerging New Therapy Against Colorectal Cancer and Human Drug Resistant Breast Cancer are among our continuous efforts and need for developing novel drug-like lead natural compounds. This book presents a remarkable anticancer activity of natural-derived compound as gingerol and its derivatives compared to the standard universal therapeutic regimen. This book describes new and modern applications of gingerols for treatment of both colorectal and breast cancer. Interestingly this book presents biological and in-silico (virtual) evaluation of potential activity of gingerols-derivatives and introduces a new hope for breast cancer patients whom developed resistance to the commonly available conventional chemotherapeutic agents. The book focuses on virtual Screening of gingerols and their derivatives, biological activity as anticolon cancer, and furthermore introducing a new therapy for human resistant breast cancer This book may introduce a new approach with evidence-based and modern use of natural products. This book may spark an interest in making further contributions to the current scientific debate and treatment development efforts.FAB Farid A. Badria, Ph.D Mansou