Alexei Verkhratsky, Arthur Morgan Butt

Glial Neurobiology

A Textbook

• Broschiertes Buch

Produktbeschreibung

Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead on neurones and neuronal networks, because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn't exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking development shave revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease.

Features of this book:
_ an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology
_ an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels
_ an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more
_ a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells

Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It will also appeal to researchers in neuroscience, physiology, pharmacology and pharmaceutics.

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Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 232
• Erscheinungstermin: 1. August 2007
• Englisch
• Abmessung: 244mm x 170mm x 13mm
• Gewicht: 454g
• ISBN-13: 9780470517406
• ISBN-10: 0470517409
• Artikelnr.: 22820424

Autorenporträt

Alexei Verkhratsky is Professor of Neurophysiology and Chairman of the Division of Neuroscience at the University of Manchester, UK. Arthur Butt is Professor of Cellular Neurophysiology, Department of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.

Inhaltsangabe

Preface. Part I. Physiology of Glia. Chapter 1. Introduction to Glia. 1.1
Founders of glial research: from Gabriel Valentin to Karl-Ludwig Schleich.
1.2 Beginning of the modern era. 1.3 Changing concepts: Glia express
molecules of excitation. 1.4 Glia and neurones in dialogue. Chapter 2.
General Overview of Signalling in the Nervous System. 2.1 Intercellular
signalling: Wiring and volume modes of transmission. 2.2 Intracellular
signalling. Chapter 3. Morphology of Glial Cells. 3.1 Astrocytes. 3.2
Oligodendrocytes. 3.3 NG2 expressing glia. 3.4 Schwann cells. 3.5
Microglia. Chapter 4. Glial Development. 4.1 Phylogeny of glia and
evolutionary specificity of glial cells in human brain. 4.2 Macroglial
cells. 4.3 Astroglial cells are brain stem cells. 4.4 Schwann cell lineage.
4.5 Microglial cell lineage. Chapter 5. General Physiology of Glial Cells.
5.1 Membrane potential and ion distribution. 5.2 Ion channels. 5.3
Receptors to neurotransmitters and neuromodulators. 5.4 Glial syncytium -
gap junctions. 5.5 Glial calcium signalling. 5.6 Neurotransmitter release
from astroglial cells. 5.7 Glial neurotransmitter transporters. 5.8 Glial
cells produce and release neuropeptides. 5.9 Glial cell derived growth
factors. Chapter 6. Neuronal-Glial Interactions. 6.1 Close apposition of
neurones and astroglia: the tripartite synapse. 6.2 Neuronal-glial
synapses. 6.3 Signalling from neurones to astrocytes 6.4 Signalling from
astrocytes to neurones. 6.5 Signalling between oligodendrocytes and
neurones. 6.6 Signalling between Schwann cells and peripheral nerves and
nerve endings. Part II. Glial Cells and Function of Nervous System. Chapter
7. Astrocytes. 7.1 Developmental function - producing new neural cells. 7.2
Developmental function - neuronal guidance. 7.3 Regulation of
synaptogenesis and control of synaptic maintenance and elimination. 7.4
Structural function - creation of the functional microarchitecture of the
brain. 7.5 Structural function - creation of glial-vascular interface.
(blood-brain barrier) and glia-neurone-vascular units. 7.6 Regulation of
brain microcirculation. 7.7 Ion homeostasis in the extracellular space. 7.8
Regulation of extracellular glutamate concentration. 7.9 Water homeostasis
and regulation of the extracellular space volume. 7.10 Neuronal metabolic
support. 7.11 Astroglia regulate synaptic transmission. 7.12 Integration in
neuronal-glial networks. 7.13 Astrocytes as cellular substrate of memory
and consciousness? Chapter 8. Oligodendrocytes, Schwann Cells and
Myelination. 8.1 The myelin sheath. 8.2 Myelination. 8.3 Myelin and
propagation of the action potential. Part III. Glia and Pathology of
Nervous System. Chapter 9. General Pathophysiology of Glia. 9.1 Reactive
astrogliosis. 9.2 Wallerian degeneration. 9.3 Activation of microglia.
Chapter 10. Glia and Diseases of the Nervous System. 10.1 Alexander's
disease. 10.2 Spreading depression. 10.3 Stroke and ischaemia. 10.4
Cytotoxic brain oedema. 10.5 Neurodegenerative diseases. 10.6 Neuropathic
pain. 10.7 Demyelinating diseases. 10.8 Infectious diseases. 10.9
Peripheral neuropathies 10.10 Psychiatric diseases. 10.11 Gliomas.
Conclusions. Recommended literature. Index.

Rezensionen

"This is a good book for neurosciences libraries." ( Doody s Book Reviews )