Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Gliosis is a proliferation of astrocytes in damaged areas of the central nervous system (CNS). This proliferation usually leads to the formation of a glial scar. Astrocytes are relatively large glial cells and have various functions, including accumulating in areas where neurons have been damaged. It is the most important histopathological sign of CNS injury. Astrocytes undergo both hypertrophy and hyperplasia. The nucleus enlarges and becomes vesicular and nucleolus becomes prominent.
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