Glycoimmunology, the studyofthe oligosaccharide components ofglycoconjugates as an integral component ofthe immune system, has opened up a rapidly evolving field. It draws from a broad spectrum of technologies, ranging from classical synthetic organic chemistry, to molecular biology and beyond. The structural microheterogenity ofoligosac charides found on glycoproteins and glycolipids is immense and reflects the enormous inherent structural diversity of these carbohydrate side chains and their ability to encode information. In this respect glycoimmunology represents an exciting and significant…mehr
Glycoimmunology, the studyofthe oligosaccharide components ofglycoconjugates as an integral component ofthe immune system, has opened up a rapidly evolving field. It draws from a broad spectrum of technologies, ranging from classical synthetic organic chemistry, to molecular biology and beyond. The structural microheterogenity ofoligosac charides found on glycoproteins and glycolipids is immense and reflects the enormous inherent structural diversity of these carbohydrate side chains and their ability to encode information. In this respect glycoimmunology represents an exciting and significant oppor tunity for both biotechnology and pharmaceutical research. This book summarizes the proceedings of the Third Jenner International Glycoim munology meeting, held at IL Ciocco Tuscany in October 1994, which was co-ordinated underthe auspicesofEUROCARB, the EuropeanCommunityConcertedAction forArthritis and Carbohydrate Research. This meeting brought together leading academic and commer cial researchers at the forefront ofglycosylation and immunology, with the aimofreviewing and focusing on applied and basic research relating to glycoimmunology and its clinical implications.
1. A Review of the Biological Significance of Carbohydrates on Glycoproteins and Methods for Their Analysis.- 2. The Different Faces of Disease: FACE® Diagnosis of Disease.- 3. Chemometrics of Oligosaccharide Analysis: Parameterization of HPLC of PA-Oligosaccharides.- 4. Molecular Modelling of Glycoproteins by Homology with Non-Glycosylated Protein Domains, Computer Simulated Glycosylation and Molecular Dynamics.- 5. Control and Function of Complex-Type Oligosaccharide Synthesis: Novel Variants of the LacNAc Pathway.- 6. The Regulation of Cell- and Tissue-Specific Expression of Glycans by Glycosyltransferases.- 7. The Genetic Regulation of Sialyl-Lex Expression in Haemopoietic Cells.- 8. Murine ?1,4-Galactosyltransferase: Analysis of a Gene that Serves both a Housekeeping and a Cell Specific Function.- 9. Cell Surface ?1,4-Galactosyltransferase: A Signal Transducing Receptor?.- 10. O-Linked N-Acetylglucosamine: The "Yin-Yang" of Ser/Thr Phosphorylation?: Nuclear and Cytoplasmic Glycosylation.- 11. Heparan Sulphate and Protein Recognition: Binding Specificities and Activation Mechanisms.- 12. Glycosylation and Maturation Rate of Membrane and Secretory Forms of Human CD8? Glycoprotein: Implications in the Activation of T-Lymphocytes.- 13. Lectin-Carbohydrate Interactions in Disease: T-Cell Recognition of IgA and IgD; Mannose Binding Protein Recognition of IgG0.- 14. Glycosylation of Antibody Molecules: A Small Step for Structure, a Leap for Function.- 15. The Effects of Altered Glycosylation of IgG on Rheumatoid Factor-Binding and Immune Complex Formation.- 16. Agalactosylation by Reactive Oxygen Species and Fc Related Changes to Function.- 17. An Introduction to Glycosylation and Rheumatic Disease: What Is the Current State of Play.- 18. Abnormalities in theGlycosylation of IgG and Its Clinical Utility.- 19. ?1,4-Galactosyltransferase Variations in Rheumatoid Arthritis.- 20. Significance and Molecular Basis for IgG Glycosylation Changes in Rheumatoid Arthritis.- 21. Immunology of Chondroitin/Dermatan Sulfate.- 22. IgA Glycosylation and Disease.- 23. IgA Nephropathy: A Disease of Incomplete IgA 1 Glycosylation?.- 24. ?1-Acid Glycoprotein: A Natural Occurring Anti-Inflammatory Molecule?.- 25. Haptoglobin: A Potential Reporter Molecule for Glycosylation Changes in Disease.- 26. Inflammatory Cytokines Controlling Branching of N-Heteroglycans of Acute Phase Protein.- 27. Cell Cycle-Related Protein Kinases and T Cell Death.- 28. Sialomucins in Inflammation and Hematopoiesis.- 29. Synthesis and Biological Activity of Oligosaccharide Libraries.- 30. In Vivo Targeting Function of N-Linked Oligosaccharides: Pharmacokinetic and Biodistribution of N-Linked Oligosaccharides.- 31. Studies on Selectin-Carbohydrate Interactions.
1. A Review of the Biological Significance of Carbohydrates on Glycoproteins and Methods for Their Analysis.- 2. The Different Faces of Disease: FACE® Diagnosis of Disease.- 3. Chemometrics of Oligosaccharide Analysis: Parameterization of HPLC of PA-Oligosaccharides.- 4. Molecular Modelling of Glycoproteins by Homology with Non-Glycosylated Protein Domains, Computer Simulated Glycosylation and Molecular Dynamics.- 5. Control and Function of Complex-Type Oligosaccharide Synthesis: Novel Variants of the LacNAc Pathway.- 6. The Regulation of Cell- and Tissue-Specific Expression of Glycans by Glycosyltransferases.- 7. The Genetic Regulation of Sialyl-Lex Expression in Haemopoietic Cells.- 8. Murine ?1,4-Galactosyltransferase: Analysis of a Gene that Serves both a Housekeeping and a Cell Specific Function.- 9. Cell Surface ?1,4-Galactosyltransferase: A Signal Transducing Receptor?.- 10. O-Linked N-Acetylglucosamine: The "Yin-Yang" of Ser/Thr Phosphorylation?: Nuclear and Cytoplasmic Glycosylation.- 11. Heparan Sulphate and Protein Recognition: Binding Specificities and Activation Mechanisms.- 12. Glycosylation and Maturation Rate of Membrane and Secretory Forms of Human CD8? Glycoprotein: Implications in the Activation of T-Lymphocytes.- 13. Lectin-Carbohydrate Interactions in Disease: T-Cell Recognition of IgA and IgD; Mannose Binding Protein Recognition of IgG0.- 14. Glycosylation of Antibody Molecules: A Small Step for Structure, a Leap for Function.- 15. The Effects of Altered Glycosylation of IgG on Rheumatoid Factor-Binding and Immune Complex Formation.- 16. Agalactosylation by Reactive Oxygen Species and Fc Related Changes to Function.- 17. An Introduction to Glycosylation and Rheumatic Disease: What Is the Current State of Play.- 18. Abnormalities in theGlycosylation of IgG and Its Clinical Utility.- 19. ?1,4-Galactosyltransferase Variations in Rheumatoid Arthritis.- 20. Significance and Molecular Basis for IgG Glycosylation Changes in Rheumatoid Arthritis.- 21. Immunology of Chondroitin/Dermatan Sulfate.- 22. IgA Glycosylation and Disease.- 23. IgA Nephropathy: A Disease of Incomplete IgA 1 Glycosylation?.- 24. ?1-Acid Glycoprotein: A Natural Occurring Anti-Inflammatory Molecule?.- 25. Haptoglobin: A Potential Reporter Molecule for Glycosylation Changes in Disease.- 26. Inflammatory Cytokines Controlling Branching of N-Heteroglycans of Acute Phase Protein.- 27. Cell Cycle-Related Protein Kinases and T Cell Death.- 28. Sialomucins in Inflammation and Hematopoiesis.- 29. Synthesis and Biological Activity of Oligosaccharide Libraries.- 30. In Vivo Targeting Function of N-Linked Oligosaccharides: Pharmacokinetic and Biodistribution of N-Linked Oligosaccharides.- 31. Studies on Selectin-Carbohydrate Interactions.
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