Glycoscience and Microbial Adhesion

Herausgegeben:Lindhorst, Thisbe K.; Oscarson, Stefan

• Gebundenes Buch

Produktbeschreibung

bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, Bitter sweetness of complexity, the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is ourhope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its guest, as well as the biological consequences resulting from this mutual interplay.

Produktdetails

• Topics in Current Chemistry 288
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 11866824, 978-3-642-01303-4
• 2009
• Seitenzahl: 200
• Erscheinungstermin: 26. Juni 2009
• Englisch
• Abmessung: 241mm x 160mm x 17mm
• Gewicht: 424g
• ISBN-13: 9783642013034
• ISBN-10: 3642013031
• Artikelnr.: 26209031

Inhaltsangabe

Bitter Sweetness of Complexity.- Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections.- Structure, Function, and Assembly of Type 1 Fimbriae.- The Multiple Carbohydrate Binding Specificities of Helicobacter pylori.- Ins and Outs of Microbial Adhesion.- Staphylococcus epidermidis Biofilms: Functional Molecules, Relation to Virulence, and Vaccine Potential.- Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions.