Glycoscience: Biology and Medicine

Herausgeber: Taniguchi, Naoyuki; Hart, Gerald W.; Endo, Tamao

• Gebundenes Buch

Produktbeschreibung

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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Produktdetails

• Verlag: Springer London / Springer Tokyo
• 2015
• Seitenzahl: 1568
• Erscheinungstermin: 1. November 2014
• Englisch
• ISBN-13: 9784431548423
• ISBN-10: 4431548424
• Artikelnr.: 40181394

Autorenporträt

Naoyuki Taniguchi is working for RIKEN, Japan. Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan. Gerald Hart is with Johns Hopkins University, USA. Peter Seeberger is with Max Planck Institute, Germany. Chi-Huey Wong is with Academia Sinica, Taiwan. The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

Inhaltsangabe

A. Analytical and Structural Approach
Technical Description for Analyzing Glycan Structures.
Overview.
EMARS.
Development of glycan array.
Development of glycan array.
Development of glycan array.
Development of glycan array.
Automated programmable one
pot synthesis of glycans.
Lectin array.
Lectin
glycan interaction based on glycan array data.
Glycoform
specific protein staining by lectin and antibody.
Glycosaminoglycans analysis.
Mass analysis.
Mass analysis.
IGOT
lectin capture.
Membrane electrophoresis.
HPLC nucleotide
sugar analysis.
Capillary electrophoresis.
HPLC PA
sugar.
Congenital disorders of glycosylation, analytical aspect.
Quality control of pharmaceutical products and biosimilars.
NMR.
NMR.
STD
NMR.
Conformational analysis of glycans and glycoproteins.
Glycolipid LC
MS.
MALDI
MS.
MALDI
MS.
Sulfoglycolipids.
GAG array.
X
ray.
REMD simulation.
MD simulation and computational screening.
B. Glycoinformatics
New Approach for Informatics and Databases for Glycoscience.
Informatics overview.
MIRAGE project.
RINGS.
JCGGDB.
UniCarb
DB.
CIRES.
GLYCOSCIENCES.de.
CSDB, Plant and Bacterial Carbohydrate Structure Database.
MonosaccharideDB.
GlycomeDB.
GlycoEpitope.
SugarBindDB.
GLYCAM.
CAZy.
3D Lectines.
C. Chemoenzymatic Synthesis of Glycans
Chemical and Enzymatic Methods of Glycan Synthesis.
Chemical synthesis of glycans.
Chemical synthesis of glycans.
Chemical synthesis of glycans.
Synthesis of homogeneous glycoproteins.
Synthesis of homogeneous glycoproteins.
Synthesis of homogeneous glycoproteins.
Synthesis of homogeneous glycoproteins.
Synthesis of homogeneous glycoproteins.
Glycopeptide/glycoprotein synthesis.
Gangliosides synthesis.
Specific Glycosylation.
Furanoside chemistry.
Glycoside synthesis.
Carbohydrate Library Synthesis.
Development of sugar array.
Development of sugar array.
Development of sugar array.
Automated synthesis.
Automation in glycan synthesis.
GPI chemical synthesis.
Oligosialic acid synthesis.
Synthesis of sulfated glycans.
Synthesis of sulfated glycans.
Synthetic antitumor vaccines.
Synthetic carbohydrate antigens for HIV Vaccine Design.
Chemical approach in biology and disease.
Glycoenzyme inhibitors.
Glycoenzyme inhibitors.
Glycoenzymes in glycan analysis and synthesis.
Endo
enzymes.
Oxazoline derivatives.
Large
scale enzymatic synthesis of glycans with cofactor regeneration.
Large
scale enzymatic synthesis of glycans.
Chemoenzymatic synthesis.
Chemoenzymatic synthesis of heparins.
Chemoenzymatic synthesis of glycoproteins.
Multivalent glycan synthesis.
Biosynthesis of A and B blood group.
Glycosyltransferase structures.
Structural biology of oligosaccharyltransferase (OST).
Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines.
Neoglycoprotein and oligosaccharide synthesis.
Chemoenzymatic synthesis of glycoconjugates.
Synthesis of O
glycosylated proteins.
D. Imaging of Glycans
New Techniques for Imaging Glycans.
Molecular probes for glycosylation: overview Imaging by Click Chemistry.
Imaging by Click Chemistry.
Imaging by Click Chemistry.
Chemical tools to detect Helicobacter pylori.
Enzymatic imaging.
PET imaging.
Glycoprotein imaging.
E. Neuroglycobiology
The Role of Glycans in Neurobiology and Neuroscience.
Neuroglycobiology overview.
Neurochemistry and developmental neurobiology.
Glycans in neurobiology.
Glycosaminoglycans (GAGs).
GAGs.
Polysialic acid.
Polysialic acid.
Glycolipids sialidase.
HNK
1.
Ganglioside.
Single molecule imaging.
Glycolipid.
Heparan sulfate proteoglycans (HSPG).
HSPG.
N
glycans and glial cells.