Gebundenes Buch

Glycosylation Engineering of Biopharmaceuticals

Methods and Protocols

Herausgegeben: Beck, Alain

Beschreibung

Glyco-engineering is being developed as a method to control the composition of carbohydrates and to enhance the pharmacological properties of monoclonal antibodies (mAbs) and other proteins. In Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols, experts in the field provide readers with production and characterization protocols of glycoproteins and glyco-engineered biopharmaceuticals with a focus on mAbs. The volume is divided in four complementary parts dealing with glyco-engineering of therapeutic proteins, glycoanalytics, glycoprotein complexes characterization, and PK/PD assays for therapeutic antibodies. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols serves as an ideal guide for scientists striving to push forward the exciting field of engineered biopharmaceuticals.

Produktdetails

• Methods in Molecular Biology 988
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 978-1-62703-326-8
• 2013
• Seitenzahl: 372
• Erscheinungstermin: 9. März 2013
• Englisch
• Abmessung: 260mm x 183mm x 25mm
• Gewicht: 825g
• ISBN-13: 9781627033268
• ISBN-10: 1627033262
• Artikelnr.: 36713453

Rezensionen

From the reviews:

"The book is intended as a reference manual of protocols and best practices for the practicing bench scientist. The authors do a marvelous job of covering a wide variety of tools and techniques and bringing them together in one volume. ... This collection of protocols will find an audience with experimentalists in the biopharmaceutical industry as well as various academic labs. ... Overall, I would strongly recommend this book ... ." (Bibhash Mukhopadhyay, Frontiers in Pharmacology, September, 2013)
"This book ... useful as it details in one place the current state of art technologies and techniques for antibodies. I enjoyed reading the introductions to each chapter, which were accessible and gave an historical setting and overall aim for the methodologies that are set out in the chapter. ... this book offers a good reference guide for those of us working in this area." (Sian Estdale, BTS Newsletter - The British Toxicology Society, Issue 43, Winter, 2013)