The best edition yet of the landmark text in medical toxicology Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins. Fully referenced and supported by a cohesive organization and full-color format, Goldfrank's begins with a…mehr
The best edition yet of the landmark text in medical toxicology Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins. Fully referenced and supported by a cohesive organization and full-color format, Goldfrank's begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations. The Eleventh Edition of Goldfrank's Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis. New to this Edition: .Additional cases and "Special Considerations" chapters designed to enhance clinical decision-making and patient outcomes .New "Antidotes in Depth" provides timely, critical information on toxicologic treatment strategies .New content on toxicogenomics explores its increasingly important role in predictive toxicology .Chapter-ending bulleted summaries of key points .Updated coverage of synthetics such as "K2" .Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment toolsHinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Mary Ann Howland, PharmD, DABAT, FAACT Clinical Professor of Pharmacy, St. Johns University College of Pharmacy; Consultant, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Senior Consultant in Residence, New York City Poison Center, New York, New York.
Inhaltsangabe
1. Historical Principles and Perspectives Paul M. Wax 2. Toxicologic Misfortunes and Catastrophes in History Paul M. Wax PART A THE GENERAL APPROACH TO THE PATIENT 3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman 4. Principles of Managing the Acutely Poisoned or Overdosed Patient Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions] SC1. Principles of Antidote Stocking [Insert author(s)] 5. Decontamination Principles: Prevention of Gastrointestinal Absorption Lotte C. G. Hoegberg and Anne-Bolette Gude SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption [Insert author(s)] A1. Activated Charcoal Silas W. Smith and Mary Ann Howland A2. Whole-Bowel Irrigation and Other Intestinal Evacuants Silas W. Smith and Mary Ann Howland 6. Principles and Techniques Applied to Enhance Elimination David S. Goldfarb and Marc Ghannoum 7. Laboratory Principles Petrie M. Rainey 8. Principles of Diagnostic Imaging David T. Schwartz 9. Pharmacokinetic and Toxicokinetic Principles Mary Ann Howland PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY SECTION I BIOCHEMICAL AND MOLECULAR CONCEPTS 10. Chemical Principles Stephen J. Traub and Lewis S. Nelson 11. Biochemical and Metabolic Principles Kurt C. Kleinschmidt and Kathleen A. Delaney 12. Fluid, Electrolyte, and Acid-Base Principles Alan N. Charney and Robert S. Hoffman 13. Neurotransmitters and Neuromodulators Steven C. Curry, Ayrn D. O'Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik 14. Withdrawal Principles Richard J. Hamilton and [new author] SECTION II PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS 15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles Cathleen Clancy 16. Cardiologic Principles II: Hemodynamics [new author] and Robert A. Hessler 17. Dermatologic Principles Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson SC3. Transdermal Toxicology Lewis S. Nelson 18. Gastrointestinal Principles Matthew D. Zuckerman and Richard J. Church 19. Genitourinary Principles Jason Chu 20. Hematologic Principles Marco L.A. Sivilotti 21. Hepatic Principles Kathleen A. Delaney 22. Neurologic Principles Rama B. Rao 23. Oncologic Principles Richard Wang 24. Ophthalmic Principles Adhi Sharma 25. Otolaryngologic Principles [new author] and William Chiang 26. Psychiatric Principles Erin A. Zerbo and Andr ea M. Kondracke 27. Renal Principles Marc Ghannoum and David S. Goldfarb 28. Respiratory Principles Andrew Stolbach and Robert S. Hoffman 29. Thermoregulatory Principles Susi U. Vassallo and Kathleen A. Delaney SECTION III SPECIAL POPULATIONS 30. Reproductive and Perinatal Principles Jeffrey S. Fine 31. Pediatric Principles Jeffrey S. Fine 32. Geriatric Principles Judith C. Ahronheim and Mary Ann Howland PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY SECTION I A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS Case Study 1 33. Acetaminophen Robert G. Hendrickson A3. N-Acetylcysteine Robert G. Hendrickson and Mary Ann Howland 34. Colchicine, Podophyllin, and the Vinca Alkaloids Joshua G. Schier 35. Nonsteroidal Antiinflammatory Drugs William J. Holubek 36. Opioids Lewis S. Nelson and Dean Olsen A4. opioid antagonists Lewis S. Nelson and Mary Ann Howland SC4. Internal Concealment of Xenobiotics Jane M. Prosser SC5. Harm Reduction for Opioid Overdose ?Josh Lee 37. Salicylates Daniel M. Lugassy A5. sodium bicarbonate Paul M. Wax B. Food, Diet, and Nutrition CASE STUDY 2 38. Botulism Howard L. Geyer A6. botulinum antitoxin Silas W. Smith and Howard L. Geyer 39. Food Poisoning [new author]and Michael Tunik 40. Dieting Xenobiotics and Regimens Jeanna M. Marraffa 41. Athletic Performance Enhancers Susi U. Vassallo 42. Essential Oils Lauren Kornreich Shawn 43. Herbal Preparations [new author] and Oliver Hung 44. Vitamins Beth Y. Ginsburg 45. Iron Jeanmarie Perrone A7. deferoxamine Mary Ann Howland C. pharmaceuticals case study 3 46. Pharmaceutical Additives Sean P. Nordt and Lisa E. Vivero 47. Antidiabetics and Hypoglycemics/Antiglycemics George M. Bosse A8. Dextrose (d-Glucose) [new author] and Larissa Velez A9. octreotide Mary Ann Howland and Silas W. Smith 48. Antiepileptics Suzanne Doyon A10. l-carnitine Mary Ann Howland 49. Antihistamines and Decongestants Sophie Gosselin A11. physostigmine salicylate Mary Ann Howland 50. Chemotherapeutics Richard Y. Wang 51. Methotrexate, 5-Flourouracil, and Capecitabine Richard Y. Wang A12. folates: leucovorin (Folinic acid) and Folic Acid Mary Ann Howland A13. glucarpidase (carboxypeptidase g2) Silas W. Smith A14. uridine triacetate Silas W. Smith SC6. Inadvertent Intrathecal Administration of Xenobiotics Rama B. Rao SC7. Extravasation of Chemotherapeutics Richard Y. Wang 52. Antimigraine Medications Jason Chu 53. Thyroid and Antithyroid Medications Nicole C. Bouchard D. Antimicrobials 54. Antibacterials, Antifungals, and Antivirals Christine M. Stork 55. Antimalarials James David Barry 56. Antituberculous Medications Christina H. Hernon A15. pyridoxine Mary Ann Howland E. Cardiopulmonary Medications CASE STUDY 4 57. Antidysrhythmics Lewis S. Nelson A16. Magnesium Sulfate Silas Smith 58. Antithrombotics Betty C. Chen and Mark Su A17. Protein Complex Concentrate and novel Antithrombotic Antidotes [Insert author(s)], Betty Chen and Mark Su A18. Vitamin k1 Mary Ann Howland A19. protamine Mary Ann Howland 59. ß-Adrenergic Antagonists Jeffrey R. Brubacher A20. Glucagon Mary Ann Howland 60. Calcium Channel Blockers David H. Jang and Francis Jerome DeRoos A21. High-dose insulin euglycemia Samuel J. Stellpflug and William Kerns, II 61. Miscellaneous Antihypertensives and Pharmacologically Related Agents Francis Jerome DeRoos 62. Cardioactive Steroids Jason B. Hack A22. digoxin-specific antibody fragments Mary Ann Howland 63. Methylxanthines and Selective ß2-Adrenergic Agonists Robert J. Hoffman F. ANESTHETICS AND RELATED MEDICATIONS 64. Local Anesthetics David R. Schwartz and Brian Kaufman A23. intravenous lipid emulsion [new author] and Todd Bania 65. Inhalational Anesthetics Brian Kaufman 66. Neuromuscular Blockers Kenneth M. Sutin A24. dantrolene sodium Kenneth M. Sutin A25. Sugammadex [new; Author] G. Psychotropics CASE STUDY 5 67. Antipsychotics David Juurlink 68. Cyclic Antidepressants Erica L. Liebelt 69. Serotonin Reuptake Inhibitors and Atypical Antidepressants Christine M. Stork 70. Lithium Howard A. Greller 71. Monoamine Oxidase Inhibitors Alex F. Manini 72. Sedative-Hypnotics David C. Lee A26. flumazenil Mary Ann Howland H. SUBSTANCES OF ABUSE CASE STUDY 6 73. Amphetamines ; David H. Jang 74. Cannabinoids Jeff M. Lapoint 75. Cocaine Jane M. Prosser and Robert S. Hoffman A27. Benzodiazepines Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland 76. Ethanol Luke Yip A28. Thiamine hydrochloride Robert S. Hoffman 77. Ethanol Withdrawal Jeffrey A. Gold and Lewis S. Nelson 78. Disulfiram and Disulfiram-like Reactions Amit K. Gupta 79. <
1. Historical Principles and Perspectives Paul M. Wax 2. Toxicologic Misfortunes and Catastrophes in History Paul M. Wax PART A THE GENERAL APPROACH TO THE PATIENT 3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman 4. Principles of Managing the Acutely Poisoned or Overdosed Patient Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions] SC1. Principles of Antidote Stocking [Insert author(s)] 5. Decontamination Principles: Prevention of Gastrointestinal Absorption Lotte C. G. Hoegberg and Anne-Bolette Gude SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption [Insert author(s)] A1. Activated Charcoal Silas W. Smith and Mary Ann Howland A2. Whole-Bowel Irrigation and Other Intestinal Evacuants Silas W. Smith and Mary Ann Howland 6. Principles and Techniques Applied to Enhance Elimination David S. Goldfarb and Marc Ghannoum 7. Laboratory Principles Petrie M. Rainey 8. Principles of Diagnostic Imaging David T. Schwartz 9. Pharmacokinetic and Toxicokinetic Principles Mary Ann Howland PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY SECTION I BIOCHEMICAL AND MOLECULAR CONCEPTS 10. Chemical Principles Stephen J. Traub and Lewis S. Nelson 11. Biochemical and Metabolic Principles Kurt C. Kleinschmidt and Kathleen A. Delaney 12. Fluid, Electrolyte, and Acid-Base Principles Alan N. Charney and Robert S. Hoffman 13. Neurotransmitters and Neuromodulators Steven C. Curry, Ayrn D. O'Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik 14. Withdrawal Principles Richard J. Hamilton and [new author] SECTION II PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS 15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles Cathleen Clancy 16. Cardiologic Principles II: Hemodynamics [new author] and Robert A. Hessler 17. Dermatologic Principles Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson SC3. Transdermal Toxicology Lewis S. Nelson 18. Gastrointestinal Principles Matthew D. Zuckerman and Richard J. Church 19. Genitourinary Principles Jason Chu 20. Hematologic Principles Marco L.A. Sivilotti 21. Hepatic Principles Kathleen A. Delaney 22. Neurologic Principles Rama B. Rao 23. Oncologic Principles Richard Wang 24. Ophthalmic Principles Adhi Sharma 25. Otolaryngologic Principles [new author] and William Chiang 26. Psychiatric Principles Erin A. Zerbo and Andr ea M. Kondracke 27. Renal Principles Marc Ghannoum and David S. Goldfarb 28. Respiratory Principles Andrew Stolbach and Robert S. Hoffman 29. Thermoregulatory Principles Susi U. Vassallo and Kathleen A. Delaney SECTION III SPECIAL POPULATIONS 30. Reproductive and Perinatal Principles Jeffrey S. Fine 31. Pediatric Principles Jeffrey S. Fine 32. Geriatric Principles Judith C. Ahronheim and Mary Ann Howland PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY SECTION I A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS Case Study 1 33. Acetaminophen Robert G. Hendrickson A3. N-Acetylcysteine Robert G. Hendrickson and Mary Ann Howland 34. Colchicine, Podophyllin, and the Vinca Alkaloids Joshua G. Schier 35. Nonsteroidal Antiinflammatory Drugs William J. Holubek 36. Opioids Lewis S. Nelson and Dean Olsen A4. opioid antagonists Lewis S. Nelson and Mary Ann Howland SC4. Internal Concealment of Xenobiotics Jane M. Prosser SC5. Harm Reduction for Opioid Overdose ?Josh Lee 37. Salicylates Daniel M. Lugassy A5. sodium bicarbonate Paul M. Wax B. Food, Diet, and Nutrition CASE STUDY 2 38. Botulism Howard L. Geyer A6. botulinum antitoxin Silas W. Smith and Howard L. Geyer 39. Food Poisoning [new author]and Michael Tunik 40. Dieting Xenobiotics and Regimens Jeanna M. Marraffa 41. Athletic Performance Enhancers Susi U. Vassallo 42. Essential Oils Lauren Kornreich Shawn 43. Herbal Preparations [new author] and Oliver Hung 44. Vitamins Beth Y. Ginsburg 45. Iron Jeanmarie Perrone A7. deferoxamine Mary Ann Howland C. pharmaceuticals case study 3 46. Pharmaceutical Additives Sean P. Nordt and Lisa E. Vivero 47. Antidiabetics and Hypoglycemics/Antiglycemics George M. Bosse A8. Dextrose (d-Glucose) [new author] and Larissa Velez A9. octreotide Mary Ann Howland and Silas W. Smith 48. Antiepileptics Suzanne Doyon A10. l-carnitine Mary Ann Howland 49. Antihistamines and Decongestants Sophie Gosselin A11. physostigmine salicylate Mary Ann Howland 50. Chemotherapeutics Richard Y. Wang 51. Methotrexate, 5-Flourouracil, and Capecitabine Richard Y. Wang A12. folates: leucovorin (Folinic acid) and Folic Acid Mary Ann Howland A13. glucarpidase (carboxypeptidase g2) Silas W. Smith A14. uridine triacetate Silas W. Smith SC6. Inadvertent Intrathecal Administration of Xenobiotics Rama B. Rao SC7. Extravasation of Chemotherapeutics Richard Y. Wang 52. Antimigraine Medications Jason Chu 53. Thyroid and Antithyroid Medications Nicole C. Bouchard D. Antimicrobials 54. Antibacterials, Antifungals, and Antivirals Christine M. Stork 55. Antimalarials James David Barry 56. Antituberculous Medications Christina H. Hernon A15. pyridoxine Mary Ann Howland E. Cardiopulmonary Medications CASE STUDY 4 57. Antidysrhythmics Lewis S. Nelson A16. Magnesium Sulfate Silas Smith 58. Antithrombotics Betty C. Chen and Mark Su A17. Protein Complex Concentrate and novel Antithrombotic Antidotes [Insert author(s)], Betty Chen and Mark Su A18. Vitamin k1 Mary Ann Howland A19. protamine Mary Ann Howland 59. ß-Adrenergic Antagonists Jeffrey R. Brubacher A20. Glucagon Mary Ann Howland 60. Calcium Channel Blockers David H. Jang and Francis Jerome DeRoos A21. High-dose insulin euglycemia Samuel J. Stellpflug and William Kerns, II 61. Miscellaneous Antihypertensives and Pharmacologically Related Agents Francis Jerome DeRoos 62. Cardioactive Steroids Jason B. Hack A22. digoxin-specific antibody fragments Mary Ann Howland 63. Methylxanthines and Selective ß2-Adrenergic Agonists Robert J. Hoffman F. ANESTHETICS AND RELATED MEDICATIONS 64. Local Anesthetics David R. Schwartz and Brian Kaufman A23. intravenous lipid emulsion [new author] and Todd Bania 65. Inhalational Anesthetics Brian Kaufman 66. Neuromuscular Blockers Kenneth M. Sutin A24. dantrolene sodium Kenneth M. Sutin A25. Sugammadex [new; Author] G. Psychotropics CASE STUDY 5 67. Antipsychotics David Juurlink 68. Cyclic Antidepressants Erica L. Liebelt 69. Serotonin Reuptake Inhibitors and Atypical Antidepressants Christine M. Stork 70. Lithium Howard A. Greller 71. Monoamine Oxidase Inhibitors Alex F. Manini 72. Sedative-Hypnotics David C. Lee A26. flumazenil Mary Ann Howland H. SUBSTANCES OF ABUSE CASE STUDY 6 73. Amphetamines ; David H. Jang 74. Cannabinoids Jeff M. Lapoint 75. Cocaine Jane M. Prosser and Robert S. Hoffman A27. Benzodiazepines Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland 76. Ethanol Luke Yip A28. Thiamine hydrochloride Robert S. Hoffman 77. Ethanol Withdrawal Jeffrey A. Gold and Lewis S. Nelson 78. Disulfiram and Disulfiram-like Reactions Amit K. Gupta 79. <
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