GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

1. ER-bound steps in the biosynthesis of G protein-coupled receptors. - 2. Role of chaperones in G protein coupled receptor signalling complex assembly. - 3. GPCR oligomerization: contribution to receptor biogenesis. - 4. The functional size of GPCRs- monomers, dimers or tetramers?. - 5. Regulation of post-Golgi traffic of G protein-coupled receptors. - 6. Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example. - 7. Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors. - 8. Chaperone-mediated assembly of G protein complexes. - 9. Synthesis and assembly of G protein bg dimers: comparison of in vitro and in vivo studies. - 10. Preferential assembly of G-abg complexes directed by the g subunits. - 11. G Protein Trafficking. - 12. Differential assembly of GPCR signaling complexes determines signaling specificity. - 13. GPCR and voltage-gated calcium channels (VGCC) signaling complexes. - 14. Pharmacological chaperones correct misfolded GPCRs and rescue function: trafficking as a therapeutic target.