With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GvHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GvHD prevention and treatment.
With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GvHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GvHD prevention and treatment.
James L. Ferrara, Kenneth R. Cooke, H. Joachim Deeg
Inhaltsangabe
The Pathophysiology of Graft vs. Host Disease. Animal Models of Graft vs. Host Disease. Graft vs. Host Disease as a Th1 Type Process: Regulation by Th2 Type Cells. Role of T Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation. Chemokines and Graft vs. Host Disease. Graft vs. Leukemia Effects. The Immune System in Graft vs. Host Disease: Target and Effector Organ. Pathology and Pathogenesis of Cutaneous Graft vs. Host Disease. Graft vs. Host Disease of the Liver. Intestinal Graft vs. Host Disease. The Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation. Clinical Spectrum of Acute Graft vs. Host Disease. Role of Minor Histocompatibility Antigens in the Development of Graft vs. Host Disease and Graft vs. Leukemia Reactivity. Advances in Tissue Typing and Their Potential Impact on GVHD Incidence and Severity. Immunosuppression and Immunophilin Ligands: Cyclosporin, Tacrolimus, and Sirolimus. Prophylaxis and Treatments of Acute Graft vs. Host Disease. Graft Manipulation to Prevent Graft vs. Host Disease. Graft vs. Host Disease in Nonmyeloablative Transplant. Adoptive Immunotherapy in Stem Cell Transplantation. Clinical Spectrum and Therapeutic Approaches to Chronic Graft vs. Host Disease. Recent Advances and Future Directions.
The Pathophysiology of Graft vs. Host Disease. Animal Models of Graft vs. Host Disease. Graft vs. Host Disease as a Th1 Type Process: Regulation by Th2 Type Cells. Role of T Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation. Chemokines and Graft vs. Host Disease. Graft vs. Leukemia Effects. The Immune System in Graft vs. Host Disease: Target and Effector Organ. Pathology and Pathogenesis of Cutaneous Graft vs. Host Disease. Graft vs. Host Disease of the Liver. Intestinal Graft vs. Host Disease. The Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation. Clinical Spectrum of Acute Graft vs. Host Disease. Role of Minor Histocompatibility Antigens in the Development of Graft vs. Host Disease and Graft vs. Leukemia Reactivity. Advances in Tissue Typing and Their Potential Impact on GVHD Incidence and Severity. Immunosuppression and Immunophilin Ligands: Cyclosporin, Tacrolimus, and Sirolimus. Prophylaxis and Treatments of Acute Graft vs. Host Disease. Graft Manipulation to Prevent Graft vs. Host Disease. Graft vs. Host Disease in Nonmyeloablative Transplant. Adoptive Immunotherapy in Stem Cell Transplantation. Clinical Spectrum and Therapeutic Approaches to Chronic Graft vs. Host Disease. Recent Advances and Future Directions.
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