Christopher Jennison, Bruce W Turnbull

Group Sequential Methods with Applications to Clinical Trials

• Gebundenes Buch

Produktbeschreibung

This book describes group sequential stopping rules designed to reduce average study length and control Type I and Type II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Group Sequential Methods with Applications to Clinical Trials effectively surveys and extends modern methods for planning and conducting interim analyses.

Produktdetails

• Verlag: Taylor and Francis
• Seitenzahl: 410
• Erscheinungstermin: 15. September 1999
• Englisch
• Abmessung: 244mm x 165mm x 27mm
• Gewicht: 680g
• ISBN-13: 9780849303166
• ISBN-10: 0849303168
• Artikelnr.: 21080268

Autorenporträt

Christopher Jennison, Bruce W. Turnbull

Inhaltsangabe

Glossary. Introduction. Two-Sided Tests: Introduction. Two-Sided Tests:
General Applications. One-Sided Tests. Two-Sided Tests with Early Stopping
Under the Null Hypothesis. Equivalence Tests. Flexible Monitoring: The
Error Spending Approach. Analysis Following a Sequential Test. Repeated
Confidence Intervals. Stochastic Curtailment. General Group Sequential
Distribution Theory. Binary Data. Survival Data. Internal Pilots Studies:
Sample Size Re-Estimation. Multiple Endpoints. Multi-Armed Trials. Adaptive
Treatment Assignment. Bayesian Approaches. Numerical Computations for Group
Sequential Tests. References
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