Anthony Noble

Growth Factor VN Complexes Accelerate the Healing of Diabetic Ulcers

Vitronectin _ Insulin Growth Factor - Insulin Growth Factor Binding Protein Complexes mediate cell migration and proliferation in skin from diabetics

• Broschiertes Buch

Produktbeschreibung

The findings outlined in this thesis show that VN:IGFBP:IGF-I complexes can elicit enhanced growth and migration in cells derived from skin from both normal and diabetic patients. Further, these responses are maintained in conditions found in the diabetic wound microenvironment, namely in the presence of high glucose and high calcium. Together these findings demonstrate the potential of the VN:IGFBP:IGF complexes as wound healing agents to treat wounds, especially diabetic ulcers. Such delayed healing wounds represent a significant burden to healthcare systems and are one of the primary conditions that leads to the amputation of limbs. Current treatments do not address the co-ordination of ECM and growth factor action on cells that is here demonstrated to stimulate multiple wound healing related functional effects in skin cells. The data presented here represents important new information that may guide the design of new integrated therapeutics which may enhance the healing of recalcitrant diabetic ulcers.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 248
• Englisch
• ISBN-13: 9783639216202
• ISBN-10: 3639216202
• Artikelnr.: 29776071

Autorenporträt

Dr Anthony Noble is Principle Scientist at Cryosite Ltd, Sydney, Australia. Anthony has previously worked for the Human Tissue Authority in London and for Tissue Therapies Ltd and the Queensland University of Technology.