Barry B. Bercu, Richard F. Walker

Growth Hormone Secretagogues in Clinical Practice

• Gebundenes Buch

Produktbeschreibung

Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practiceanalyzes structural requirements for GH secretagogue efficacy demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary reports on the development of a simple screening system based on polyclonal antibodies discusses laboratory synthesis of agonistic analogs intended for human and veterinary use proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons and much more!

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 464
• Erscheinungstermin: 28. April 1998
• Englisch
• Abmessung: 235mm x 157mm x 32mm
• Gewicht: 899g
• ISBN-13: 9780824798321
• ISBN-10: 0824798325
• Artikelnr.: 21979255

Autorenporträt

Bercu, Barry B.; Walker, Richard F.

Inhaltsangabe

Part 1 Scope of non-GHRH growth hormone secretagogues: synergistic release
of growth hormone by GHRP and GHRH - scope and implication; structural
requirements of growth hormone secretagogues; unifying mechanism of
non-GHRH growth hormonesecretagogues's action; molecular cloning and
characterization of human, swine and rat growth hormone secretagogues
receptors; a mathematical model for growth hormone release from the
pituitary; evidence for a new subtype of GHRP receptors in ovinepituitary
gland. Part 2 Experimental pharmacology: agonists analogs of growth
hormone-releasing hormone - endocrine and growth studies; antagonistic
analogs of growth hormone-releasing hormone - endocrine and oncological
studies; clinical evidence forextrahypophyseal site of growth hormone
secretagogues; electrophysiological studies of the arcuate nucleus -
central actions of growth hormone secretagogues; effects of a growth
hormone-releasing peptide-like nonpeptidyl growth hormone secretagogue
onphysiology and function on aged rats; anterior pituitary function in
prolonged critical illness - effects of continuous infusion of growth
hormone secretagogues; hepatic extraction of hexarelin, a new peptide
growth hormone secretagogue, in the isolatedperfused rat liver; the effect
of growth hormone secretagogues on the release of growth hormone-releasing
hormone, somatostatin, vasopressin and corticotrophin-releasing hormone
from the rat hypothalamus in vitro; immunocytochemical studies
investigatingthe central actions of the nonpeptidyl growth hormone
secretagogue, MK-0677. Part 3 Clinical applications of growth hormone
secretagogues: evaluation of pituitary function using growth hormone
secretagogues; clinical use of growth hormone secretagogues;short- and
long-term growth hormone secretagogue administration in children; endocrine
response to growth hormone-releasing peptides across human life span; GHRH
and GHRP-5 exert different effects on sleep electroencephalograms and
nocturnal hormonesecretion in normal men. (Part contents).