Gillian Rozenberg

Guide to Paediatric Haematology Morphology

• Gebundenes Buch

Produktbeschreibung

This illustrated guide to identifying or confirming blood disorders in paediatric patients presents examples of the abnormal morphology involved. Clinicians in both Haematology and Paediatrics will find this an invaluable resource.

Produktdetails

• Verlag: Taylor & Francis Ltd
• Seitenzahl: 107
• Erscheinungstermin: 15. August 2024
• Englisch
• Abmessung: 254mm x 178mm
• ISBN-13: 9781032755373
• ISBN-10: 1032755377
• Artikelnr.: 70149960

Autorenporträt

Gillian Rozenberg, Consultant in blood film morphology, FAIMS (Life Member), FFSc (RCPA) is the Principal Medical Scientist working in the field of Diagnostic Haematology at the Prince of Wales Hospital, Sydney, Australia.

Inhaltsangabe

Acknowledgements
Introduction
Examination of the Blood Film. Preparation of the film. Examination of the
film. Artefactual changes seen on the blood film. White cell artefact. Poor
staining. Crush artefact. Platelet artefact. Red cell classification.
Significance of the red cell distribution width (RDW).
Section 1: Red Cells
Erythrocytes in the neonate and childhood: Are they macrocytic, normocytic,
or microcytic (why the change in size?). Foetomaternal haemorrhage. The art
of blood film morphology. Red cell reference ranges. Reticulocyte reference
ranges. Electron microscopic image of normal red cells. Cord blood. Anaemia
in the neonate. ABO incompatibility. Rh haemolytic disease of the newborn.
Twin to twin haemorrhage prior to birth. Erythroblastosis fetalis.
Haemoglobin disorders. The a thalassaemias. Silent carrier a-thalassaemia
trait. a- thalassaemia trait. Haemoglobin H disease. Haemoglobin H disease
cresyl blue. Hydrops fetalis. Haemoglobin constant spring (HbCS). The ß
thalassaemias. Silent carrier ß thalassaemia trait. ß-thalassaemia trait.
ß-thalassaemia intermedia. ß-thalassaemia major. Abnormal haemoglobins.
Haemoglobin C. HBC trait. HBCC disease. In vitro test for detection of HBC.
Haemoglobin E. HBE trait. HBEE disease. Hb E/thalassaemia. Hb E/ß
thalassaemia. Hb S/ß thalassaemia. HB haemoglobin S. HBS trait. HBSS
disease. In vitro sickling test for detection of HBS. Red cell membrane
disorders. Herederitary spherocytosis. Hereditary elliptocytosis.
South-east Asian ovalocytosis. Heredeitary stomatocytosis (Hydrocytosis).
Hereditary xerocytosis. Heredeitary pyropoikilocytosis (HPP).
Abetalipoproteinaemia. Vitamin E deficiency. Liver disease. Burns (third
degree). Diamond blackfan anaemia (DBA). Haemolytic anaemias. Haemolytic
anaemia dure to lead poisoning. Oxidant-drug-induced haemolytic anaemia.
Pyruvate kinase (PK) deficiency. Autoimmune haemolytic anaemia (AIHA).
Microangiopathic haemolytic anaemia. Valvular heart disease. Haemolytic
uraemic syndrome (HUS). Thrombotic thrombocytopenic purpura (TTP). Marfan's
syndrome. Disseminated intravascular coagulation (DIC). Malignancy. HELLP
syndrome. Paroxysmal cold haemoglobinuria (PCH). Congenital sideroblastic
anaemia. Transient erythroblastopenia of childhood (TEC). Recovert from
TEC. Miscellaneous red cell images. Splenectomy - Howell Jolly bodies.
Splenectomy - Acanthocytes. Lipaemic plasma.
Section 2: White Cells
White cell reference ranges in infancy and childhood. Myeloid maturation.
Myeloblast. Promyelocyte. Myelocyte. Metamyelocyte. Band form. Neutrophil.
Eosinophil. Basophil. Abnormal Myeloid Cells. Pelger-Huët anomaly.
Hypersegmented neutrophil. Hypergranulated neutrophils. Toxic vacuolation.
Döhle bodies. Leukaemoid reaction. Kawasaki disease. Alder-Reilly anomaly.
Mucopolysaccharidosis Type VI (MPS VI). Chédiak-Higashi anomaly.
Basophilia/Mastocytosis. Cutaneous mastocytosis (CM). Mast cell leukaemia
(MCL). Neonatal neutrophilia. Sepsis in the neonate. Bone marrow failure.
Aplastic anaemia. Dyskeratosis congenita (DC). Pancytopenias. Fanconi
anaemia (FA). Shwachman-Diamond syndrome (SDS). Neutropenia. Cyclic
neutropenia. Kostmann syndrome. Eosinophilia. Eosinophilia in the neonate.
Eosinophilia in early childhood. Leucoerythoblastosis. Osteopetrosis.
Myeloproliferative neoplasms in the neonate and childhood. Transient
abnormal myelopoiesis (TAM). Monocytes and macrophages. Monocytic
maturation. Monoblast. Promonocyte. Monocyte. Gaucher disease. Niemann-Pick
disease. Reactive haemophagocytic syndrome. Langerhans cell histiocytosis
(LCH). Storage disorders in the neonate and childhood. a-Mannosidosis.
Mucopolysaccharidoses. Hurler syndrome (Gasser lymphocytes). Cystinosis.
Wolman disease. Monosomy 7 myeloproliferative disease (MPD). Cytogenetics.
Juvenile myelomonocytic leukaemia (JMML). Cytogenetics. Myelodysplastic
syndromes (MDS). Lymphocytes. Lymphocyte maturation. Lymphoblast.
Prolymphocyte. Lymphocyte (small). Lymphocyte (large). Reactive
lymphocytosis. Reactive lymphocytes (Infectious mononucleosis) (IM).
Cytomegalovirus (CMV) infection. Varicella infection. Viral hepatitis.
Bordetella pertussis. Acute infectious lymphocytosis. Sialic acid storage
disease. Non-haemopoietic malignancies in the neonate and childhood.
Neuroblastoma. Rhabdomyosarcoma. Ewing sarcoma.
Section 3: Platelets
Platelet reference ranges in infancy and childhood. Megakaryocytic
maturation. Megakaryoblast. Promegakaryocytes. Megakaryocyte. Platelet
abnormalities. Reactive thrombocytosis. Large and giant platelets. Platelet
aggregates. Platelet satellitism. Thrombocytopenia. Thrombocytopenia due to
increased destruction (ITP). Thrombocytopenia due to impaired or
ineffective thrombopoiesis. Amegakaryocytic thrombocytopenia (AMEGA).
Bernard-Soulier syndrome (BSS). Gray platelet syndrome (GPS). May-Hegglin
anomaly (MHA). Thrombocytopenia with absent radii (TAR). Wiskott-Aldrich
syndrome (WAS). Thrombocytosis. Lymphoproliferative neoplasms. B
lymphoblastic leukaemia/lymphoma. T-lymphoblastic leukaemia.
Immunophenotype. T lymphoblastic leukaemia/lymphoma. Immunophenotype.
Index.