3D-guided endodontics is a cutting-edge, technology-driven method that provides a secure and dependable solution for addressing both partial and complete root canal calcifications, as well as root end surgeries. Advances in CBCT imaging and software now allow clinicians to easily evaluate root canal anatomy, project canal pathways, and estimate working lengths, facilitating accurate pre-treatment planning. This technology also allows for the creation of precise jaw models, eliminating the need for potentially distorted and inconvenient impressions. Additionally, this book will emphasize the vital role of STL files in 3D printing within endodontic procedures.