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High Quality Content by WIKIPEDIA articles! A Guideline Execution Engine is a computer program which can interpret a clinical guideline represented in a computerized format and perform actions towards the user of an electronic medical record. A Guideline Execution Engine needs to communicate with a host Clinical information system. vMR is one possible interface which can be used. The engine's main function is to manage instances of executed guidelines of individual patients. Delivering the inferred engine recommendations or impacts to the host Clinical information system has to carefully respect current workflow of the clinicians (physicians, nurses, clerks, etc.)