The second edition of Hallelujah Moments shares exciting stories-old and new-of pharmaceutical drug discovery to reveal how and why drugs are made.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Eugene H. Cordes previously served as Vice President of Biochemistry and Molecular Biology in the Research Laboratories of Merck and Company and as President of Research and Development at Sterling Winthrop Pharmaceuticals Inc. During his career, he received awards for his classroom instruction at both Indiana University and the University of Michigan. He is the author of The Tao of Chemistry and Life (OUP 2009) and several biochemistry textbooks.
Inhaltsangabe
* Preface * Acknowledgments * 1. Seduced by Drug Discovery * 2. Proscar and Propecia: the Gary and Jerry Show * 3. Basic research, snake venoms and ACE inhibitors: Ondetti, Cushman and Patchett * 4. HIV protease inhibitors: weapons in the way against HIV/AIDS * 5. Statins: protection against heart attacks and strokes - Hallelujah * 6. The perils of Primaxin * 7. The discovery of taxol: Wall, Horwitz, Holton * 8. Avermectins: molecules of life battle parasites * 9. Fludalanine: nice try but no cigar * 10. Diabetes breakthroughs: Thornberry and Weber * 11. Take it off! Take it all off! Drugs for weight reduction * 12. The conquest of hepatitis C: telaprevir and beyond * Appendix A: The small molecules of life: some basics of chemistry * Appendix B: The basics of protein structure * Appendix C: Proteins perform multiple functions: enzymes, receptors, ion channels * Appendix D: The basics of drug discovery and development * Appendix E: Structures of key molecules
* Preface * Acknowledgments * 1. Seduced by Drug Discovery * 2. Proscar and Propecia: the Gary and Jerry Show * 3. Basic research, snake venoms and ACE inhibitors: Ondetti, Cushman and Patchett * 4. HIV protease inhibitors: weapons in the way against HIV/AIDS * 5. Statins: protection against heart attacks and strokes - Hallelujah * 6. The perils of Primaxin * 7. The discovery of taxol: Wall, Horwitz, Holton * 8. Avermectins: molecules of life battle parasites * 9. Fludalanine: nice try but no cigar * 10. Diabetes breakthroughs: Thornberry and Weber * 11. Take it off! Take it all off! Drugs for weight reduction * 12. The conquest of hepatitis C: telaprevir and beyond * Appendix A: The small molecules of life: some basics of chemistry * Appendix B: The basics of protein structure * Appendix C: Proteins perform multiple functions: enzymes, receptors, ion channels * Appendix D: The basics of drug discovery and development * Appendix E: Structures of key molecules
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