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Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use - Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology - Retains a succinct chapter…mehr
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Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use
- Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology
- Retains a succinct chapter format that has become the hallmark for the previous editions
- Distils a vast amount of information into one resource for both academics and professionals
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
- Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use
- Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology
- Retains a succinct chapter format that has become the hallmark for the previous editions
- Distils a vast amount of information into one resource for both academics and professionals
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14592973000
- 6. Aufl.
- Seitenzahl: 1384
- Erscheinungstermin: 13. April 2015
- Englisch
- Abmessung: 287mm x 222mm x 58mm
- Gewicht: 3012g
- ISBN-13: 9780470929735
- ISBN-10: 0470929731
- Artikelnr.: 42054705
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14592973000
- 6. Aufl.
- Seitenzahl: 1384
- Erscheinungstermin: 13. April 2015
- Englisch
- Abmessung: 287mm x 222mm x 58mm
- Gewicht: 3012g
- ISBN-13: 9780470929735
- ISBN-10: 0470929731
- Artikelnr.: 42054705
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
Raymond Harbison is a Professor of Environmental and Occupational Health and of Pathology and Pharmacology at the University of South Florida. He has more than thirty years of experience as a toxicologist, pharmacologist, and human health risk assessor. Marie Bourgeois is a Research Assistant Professor at University of South Florida. With Masters and Doctorate degrees in Toxicology and Risk Assessment, she teaches undergraduate courses related to environmental, occupational, and public health. Giffe Johnson is a Research Assistant Professor at University of South Florida. He has published and presented research on a variety of topics related to environmental and occupational health.
Contributors xiii
Abbreviations xvii
The Heritage of Alice Hamilton MD and Harriet Hardy MD xix
In Memory xxi
Preface xxiii
Section I Introduction 1
Section Editor: Raymond D. Harbison
1 The Modern Approach to the Diagnosis of Occupational Disease 3
Raymond D. Harbison and Jeffrey H. Mandel
2 Controls of Occupational Diseases 13
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section II Metals and Metalloids 19
Section Editor: Richard V. Lee
3 Introduction 21
Richard V. Lee
4 Alkali Compounds 25
Steve Morris and Ann Lurati
5 Aluminum 33
Giffe T. Johnson
6 Antimony 39
Marie M. Bourgeois
7 Arsenic 45
Janice S. Lee and Santhini Ramasamy
8 Barium 57
Marie M. Bourgeois
9 Beryllium 63
Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73
Paul Jonmaire
11 Boron 79
Giffe T. Johnson
12 Cadmium 85
Frank D. Stephen
13 Chromium 95
Kathleen Macmahon
14 Cobalt 101
Davinderjit Singh and Raymond D. Harbison
15 Copper 109
Marie M. Bourgeois
16 Gallium and Indium 115
Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119
Marek Banasik
18 Gold 123
Marek Banasik
19 Iron 127
Steve Morris and Jayme P. Coyle
20 Lead 131
Frank D. Stephen
21 Lithium 141
Ushang Desai
22 Manganese 149
Alex Lebeau
23 Mercury 157
Frank D. Stephen
24 Molybdenum 167
Paul Jonmaire
25 Nickel 173
Robyn L. Prueitt and Julie E. Goodman
26 Tantalum and Niobium 183
Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187
Alex Lebeau
28 Platinum 193
Alex Lebeau
29 Rare Earth Metals 199
Raymond D. Harbison and David R. Johnson
30 Selenium and its Compounds 205
Anna M. Fan and Marco Vinceti
31 Silver 229
Giffe T. Johnson
32 Tellurium 233
Marek Banasik
33 Thallium 239
Nikolay M. Filipov
34 Tin 247
Raymond D. Harbison and David R. Johnson
35 Titanium 253
Ushang Desai and Raymond D. Harbison
36 Tungsten 257
Kambria K. Haire and Raymond D. Harbison
37 Vanadium 261
James C. Ball and Maureen R. Gwinn
38 Zinc 277
Giffe T. Johnson
39 Hafnium and Zirconium 283
Kambria K. Haire, Jayme P. Coyle, and Raymond D. Harbison
40 Metal Fume Fever and Metal-Related Lung Disease 289
Thomas Truncale
Section III Chemical Compounds I 301
Section Editor: Raymond D. Harbison
41 Introduction 303
Raymond D. Harbison
42 Carbon Dioxide 305
Debra J. Price
43 Carbon Monoxide 309
Erin L. Pulster and James V. Hillman
44 Carbon Disulfide 317
Debra J. Price
45 Hydrogen Sulfide 325
Stephen C. Harbison and Jacob R. Bourgeois
46 Cyanide 331
Erin L. Pulster and James V. Hillman
47 Halogens 341
Joseph A. Puccio
48 Phosgene 357
Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto
49 Nitrogen Compounds 363
Kathleen T. Jenkins
50 Oxygen and Ozone 371
Robert A. Klocke
51 Phosphorus Compounds 383
M. Rony Francois and Frank Stephen
52 Sulfur Compounds 391
Frank Stephen and M. Rony Francois
Section IV Organic Compounds 401
Section Editor: Raymond D. Harbison
53 Aliphatic Hydrocarbons 403
Mayowa Amosu, Nicole Nation, and Mary Alice Smith
54 Alcohols and Glycols 419
Kelly W. Hall
55 Aldehydes and Ketones 445
Jason S. Garcia and Raymond D. Harbison
56 Ethers and Epoxides 491
Erin L. Pulster, Jacob R. Bourgeois, and Raymond D. Harbison
57 Esters 505
Raymond D. Harbison and C. Clifford Conaway
58 Chlorinated Hydrocarbons 541
Michael H. Lumpkin
59 Other Halogenated Hydrocarbons 567
Michael H. Lumpkin
60 Aromatic Hydrocarbons 581
Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson, and Marie M.
Bourgeois
61 Amino and Nitro Compounds 615
David Y. Lai and Yin-Tak Woo
62 Methyl Tert-Butyl Ether (MTBE) 643
Janice S. Lee and Robyn Blain
63 Ethyl Tertiary Butyl Ether (ETBE) 651
Keith D. Salazar
64 tert-Butyl Alcohol 657
Janice S. Lee
65 Naphthalene 663
Lisa A. Bailey, Laura E. Kerper, and Lorenz R. Rhomberg
66 Gasoline (Petrol, Motor Spirits, Motor Fuel, Natural Gasoline, Benzin,
Mogas) 669
Raymond D. Harbison and Daniel A. Newfang
67 1-Bromopropane 677
Marek Banasik
68 Diacetyl 683
David J. Hewitt
69 Perfluoroalkyl Compounds 689
Jason S. Garcia and Raymond D. Harbison
70 Tetrahydrofuran 719
Ghazi A. Dannan
71 Perchloroethylene (Tetrachloroethylene) 727
David G. Dodge and Julie E. Goodman
72 Trichloroethylene 733
David G. Dodge and Julie E. Goodman
73 Acrylonitrile 741
Jason M. Fritz and April M. Luke
Section V Organic High Polymers, Monomers, and Polymer Additives 755
Section Editor: Raymond D. Harbison
74 Introduction 757
Raymond D. Harbison
75 Plastics 759
Marek Banasik
76 Elastomers 785
Marek Banasik
77 Synthetic Fibers 791
Marek Banasik
78 Bisphenol A (4,4¿-Isopropylidenediphenol) 795
Julie E. Goodman, Lorenz R. Rhomberg, and Michael K. Peterson
79 Polystyrene/Styrene 809
Leslie A. Beyer and Julie E. Goodman
80 Phthalates 815
Robert W. Benson
81 Decabromodiphenyl Ethane 821
Marek Banasik
82 Tetrabromobisphenol A 827
David Y. Lai
83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik
84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845
Marek Banasik
Section VI Pesticides 855
Section Editor: Raymond D. Harbison
85 Introduction 857
Raymond D. Harbison
86 Insecticides 859
Carol S. Wood
87 Herbicides 877
Giffe T. Johnson
88 Fungicides 901
Amora Mayo-Perez and Raymond D. Harbison
89 Rodenticides 917
Daniel L. Sudakin
Section VII Dusts and Fibers 927
Section Editor: Raymond D. Harbison
90 Introduction 929
David R. Johnson
91 Benign Dusts (Nuisance Dusts) 931
Humairat H. Rahman and Raymond D. Harbison
92 Fibrogenic Dusts 935
Charles Barton
93 Mixed Dusts 949
Charles Barton
94 Synthetic Vitreous Fibers 959
Thomas Truncale and Yehia Y. Hammad
95 Organic Dusts 969
David R. Johnson
96 Naturally Occurring Mineral Fibers 997
Ali K. Hamade, Christopher M. Long, and Peter A. Valberg
97 Nanoparticles 1025
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section VIII Physical Agents 1029
Section Editor: Marie Bourgeois
98 Radio-Frequency Radiation 1031
R. Timothy Hitchcock
99 Optical Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045
Joseph M. Greco
100 Ionizing Radiation 1055
Thomas A. Lewandowski, Juhi K. Chandalia, and Peter A. Valberg
101 Electromagnetic Waves (EMF and RF) and Health Effects 1069
Peter A. Valberg
102 Traumatogens Associated with Carpal Tunnel Syndrome 1087
Joan M. Watkins
103 Vibration 1099
Donald E. Wasserman
104 Occupational Noise 1115
David L. Dahlstrom
105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson
Section IX Special Topics 1129
Section Editor: Raymond D. Harbison
106 Mode of Action/Human Relevance Framework 1131
M.E. (Bette) Meek
107 Carcinogenesis 1135
Carlos A. Muro-Cacho
108 Genotoxicity Testing Strategies, Guidelines, and Methods 1173
Ching-hung Hsu and Qingli Wang
109 Human Relevance of Rodent Leydig Cell Tumors 1189
Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F. Hardisty
110 Reproductive Toxicology 1197
Judith W. Henck
111 Developmental Toxicology 1229
Thomas A. Lewandowski
112 Ototoxicity 1241
Matthew Mifsud and K. Paul Boyev
113 Dermal and Ocular Toxicity 1247
Jayme P. Coyle, Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois,
and Raymond D. Harbison
114 Reactive Airways Dysfunction Syndrome (RADS) 1259
David J. Hewitt
115 Pulmonary Sensitization 1263
David J. Hewitt
116 "Street" and Prescription Drug Abuse 1267
Sharon S. Kelley, James Godin, and John Christie
117 Mycotoxins 1283
Clara Y. Chan and Bruce J. Kelman
118 Phosphine 1295
Michael W. Perkins, Benjamin Wong, Dorian Olivera, and Alfred Sciuto
119 Diesel Exhaust 1301
J. Michael Berg, Phillip T. Goad, and Thomas W. Hesterberg
120 Spaceflight Operations 1311
Michael A. Cardinale, Philip J. Scarpa, James R. Taffer, and Daniel Woodard
121 Regulatory Toxicology 1321
David M. Polanic and Marek Banasik
Index 1331
Abbreviations xvii
The Heritage of Alice Hamilton MD and Harriet Hardy MD xix
In Memory xxi
Preface xxiii
Section I Introduction 1
Section Editor: Raymond D. Harbison
1 The Modern Approach to the Diagnosis of Occupational Disease 3
Raymond D. Harbison and Jeffrey H. Mandel
2 Controls of Occupational Diseases 13
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section II Metals and Metalloids 19
Section Editor: Richard V. Lee
3 Introduction 21
Richard V. Lee
4 Alkali Compounds 25
Steve Morris and Ann Lurati
5 Aluminum 33
Giffe T. Johnson
6 Antimony 39
Marie M. Bourgeois
7 Arsenic 45
Janice S. Lee and Santhini Ramasamy
8 Barium 57
Marie M. Bourgeois
9 Beryllium 63
Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73
Paul Jonmaire
11 Boron 79
Giffe T. Johnson
12 Cadmium 85
Frank D. Stephen
13 Chromium 95
Kathleen Macmahon
14 Cobalt 101
Davinderjit Singh and Raymond D. Harbison
15 Copper 109
Marie M. Bourgeois
16 Gallium and Indium 115
Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119
Marek Banasik
18 Gold 123
Marek Banasik
19 Iron 127
Steve Morris and Jayme P. Coyle
20 Lead 131
Frank D. Stephen
21 Lithium 141
Ushang Desai
22 Manganese 149
Alex Lebeau
23 Mercury 157
Frank D. Stephen
24 Molybdenum 167
Paul Jonmaire
25 Nickel 173
Robyn L. Prueitt and Julie E. Goodman
26 Tantalum and Niobium 183
Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187
Alex Lebeau
28 Platinum 193
Alex Lebeau
29 Rare Earth Metals 199
Raymond D. Harbison and David R. Johnson
30 Selenium and its Compounds 205
Anna M. Fan and Marco Vinceti
31 Silver 229
Giffe T. Johnson
32 Tellurium 233
Marek Banasik
33 Thallium 239
Nikolay M. Filipov
34 Tin 247
Raymond D. Harbison and David R. Johnson
35 Titanium 253
Ushang Desai and Raymond D. Harbison
36 Tungsten 257
Kambria K. Haire and Raymond D. Harbison
37 Vanadium 261
James C. Ball and Maureen R. Gwinn
38 Zinc 277
Giffe T. Johnson
39 Hafnium and Zirconium 283
Kambria K. Haire, Jayme P. Coyle, and Raymond D. Harbison
40 Metal Fume Fever and Metal-Related Lung Disease 289
Thomas Truncale
Section III Chemical Compounds I 301
Section Editor: Raymond D. Harbison
41 Introduction 303
Raymond D. Harbison
42 Carbon Dioxide 305
Debra J. Price
43 Carbon Monoxide 309
Erin L. Pulster and James V. Hillman
44 Carbon Disulfide 317
Debra J. Price
45 Hydrogen Sulfide 325
Stephen C. Harbison and Jacob R. Bourgeois
46 Cyanide 331
Erin L. Pulster and James V. Hillman
47 Halogens 341
Joseph A. Puccio
48 Phosgene 357
Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto
49 Nitrogen Compounds 363
Kathleen T. Jenkins
50 Oxygen and Ozone 371
Robert A. Klocke
51 Phosphorus Compounds 383
M. Rony Francois and Frank Stephen
52 Sulfur Compounds 391
Frank Stephen and M. Rony Francois
Section IV Organic Compounds 401
Section Editor: Raymond D. Harbison
53 Aliphatic Hydrocarbons 403
Mayowa Amosu, Nicole Nation, and Mary Alice Smith
54 Alcohols and Glycols 419
Kelly W. Hall
55 Aldehydes and Ketones 445
Jason S. Garcia and Raymond D. Harbison
56 Ethers and Epoxides 491
Erin L. Pulster, Jacob R. Bourgeois, and Raymond D. Harbison
57 Esters 505
Raymond D. Harbison and C. Clifford Conaway
58 Chlorinated Hydrocarbons 541
Michael H. Lumpkin
59 Other Halogenated Hydrocarbons 567
Michael H. Lumpkin
60 Aromatic Hydrocarbons 581
Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson, and Marie M.
Bourgeois
61 Amino and Nitro Compounds 615
David Y. Lai and Yin-Tak Woo
62 Methyl Tert-Butyl Ether (MTBE) 643
Janice S. Lee and Robyn Blain
63 Ethyl Tertiary Butyl Ether (ETBE) 651
Keith D. Salazar
64 tert-Butyl Alcohol 657
Janice S. Lee
65 Naphthalene 663
Lisa A. Bailey, Laura E. Kerper, and Lorenz R. Rhomberg
66 Gasoline (Petrol, Motor Spirits, Motor Fuel, Natural Gasoline, Benzin,
Mogas) 669
Raymond D. Harbison and Daniel A. Newfang
67 1-Bromopropane 677
Marek Banasik
68 Diacetyl 683
David J. Hewitt
69 Perfluoroalkyl Compounds 689
Jason S. Garcia and Raymond D. Harbison
70 Tetrahydrofuran 719
Ghazi A. Dannan
71 Perchloroethylene (Tetrachloroethylene) 727
David G. Dodge and Julie E. Goodman
72 Trichloroethylene 733
David G. Dodge and Julie E. Goodman
73 Acrylonitrile 741
Jason M. Fritz and April M. Luke
Section V Organic High Polymers, Monomers, and Polymer Additives 755
Section Editor: Raymond D. Harbison
74 Introduction 757
Raymond D. Harbison
75 Plastics 759
Marek Banasik
76 Elastomers 785
Marek Banasik
77 Synthetic Fibers 791
Marek Banasik
78 Bisphenol A (4,4¿-Isopropylidenediphenol) 795
Julie E. Goodman, Lorenz R. Rhomberg, and Michael K. Peterson
79 Polystyrene/Styrene 809
Leslie A. Beyer and Julie E. Goodman
80 Phthalates 815
Robert W. Benson
81 Decabromodiphenyl Ethane 821
Marek Banasik
82 Tetrabromobisphenol A 827
David Y. Lai
83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik
84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845
Marek Banasik
Section VI Pesticides 855
Section Editor: Raymond D. Harbison
85 Introduction 857
Raymond D. Harbison
86 Insecticides 859
Carol S. Wood
87 Herbicides 877
Giffe T. Johnson
88 Fungicides 901
Amora Mayo-Perez and Raymond D. Harbison
89 Rodenticides 917
Daniel L. Sudakin
Section VII Dusts and Fibers 927
Section Editor: Raymond D. Harbison
90 Introduction 929
David R. Johnson
91 Benign Dusts (Nuisance Dusts) 931
Humairat H. Rahman and Raymond D. Harbison
92 Fibrogenic Dusts 935
Charles Barton
93 Mixed Dusts 949
Charles Barton
94 Synthetic Vitreous Fibers 959
Thomas Truncale and Yehia Y. Hammad
95 Organic Dusts 969
David R. Johnson
96 Naturally Occurring Mineral Fibers 997
Ali K. Hamade, Christopher M. Long, and Peter A. Valberg
97 Nanoparticles 1025
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section VIII Physical Agents 1029
Section Editor: Marie Bourgeois
98 Radio-Frequency Radiation 1031
R. Timothy Hitchcock
99 Optical Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045
Joseph M. Greco
100 Ionizing Radiation 1055
Thomas A. Lewandowski, Juhi K. Chandalia, and Peter A. Valberg
101 Electromagnetic Waves (EMF and RF) and Health Effects 1069
Peter A. Valberg
102 Traumatogens Associated with Carpal Tunnel Syndrome 1087
Joan M. Watkins
103 Vibration 1099
Donald E. Wasserman
104 Occupational Noise 1115
David L. Dahlstrom
105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson
Section IX Special Topics 1129
Section Editor: Raymond D. Harbison
106 Mode of Action/Human Relevance Framework 1131
M.E. (Bette) Meek
107 Carcinogenesis 1135
Carlos A. Muro-Cacho
108 Genotoxicity Testing Strategies, Guidelines, and Methods 1173
Ching-hung Hsu and Qingli Wang
109 Human Relevance of Rodent Leydig Cell Tumors 1189
Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F. Hardisty
110 Reproductive Toxicology 1197
Judith W. Henck
111 Developmental Toxicology 1229
Thomas A. Lewandowski
112 Ototoxicity 1241
Matthew Mifsud and K. Paul Boyev
113 Dermal and Ocular Toxicity 1247
Jayme P. Coyle, Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois,
and Raymond D. Harbison
114 Reactive Airways Dysfunction Syndrome (RADS) 1259
David J. Hewitt
115 Pulmonary Sensitization 1263
David J. Hewitt
116 "Street" and Prescription Drug Abuse 1267
Sharon S. Kelley, James Godin, and John Christie
117 Mycotoxins 1283
Clara Y. Chan and Bruce J. Kelman
118 Phosphine 1295
Michael W. Perkins, Benjamin Wong, Dorian Olivera, and Alfred Sciuto
119 Diesel Exhaust 1301
J. Michael Berg, Phillip T. Goad, and Thomas W. Hesterberg
120 Spaceflight Operations 1311
Michael A. Cardinale, Philip J. Scarpa, James R. Taffer, and Daniel Woodard
121 Regulatory Toxicology 1321
David M. Polanic and Marek Banasik
Index 1331
Contributors xiii
Abbreviations xvii
The Heritage of Alice Hamilton MD and Harriet Hardy MD xix
In Memory xxi
Preface xxiii
Section I Introduction 1
Section Editor: Raymond D. Harbison
1 The Modern Approach to the Diagnosis of Occupational Disease 3
Raymond D. Harbison and Jeffrey H. Mandel
2 Controls of Occupational Diseases 13
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section II Metals and Metalloids 19
Section Editor: Richard V. Lee
3 Introduction 21
Richard V. Lee
4 Alkali Compounds 25
Steve Morris and Ann Lurati
5 Aluminum 33
Giffe T. Johnson
6 Antimony 39
Marie M. Bourgeois
7 Arsenic 45
Janice S. Lee and Santhini Ramasamy
8 Barium 57
Marie M. Bourgeois
9 Beryllium 63
Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73
Paul Jonmaire
11 Boron 79
Giffe T. Johnson
12 Cadmium 85
Frank D. Stephen
13 Chromium 95
Kathleen Macmahon
14 Cobalt 101
Davinderjit Singh and Raymond D. Harbison
15 Copper 109
Marie M. Bourgeois
16 Gallium and Indium 115
Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119
Marek Banasik
18 Gold 123
Marek Banasik
19 Iron 127
Steve Morris and Jayme P. Coyle
20 Lead 131
Frank D. Stephen
21 Lithium 141
Ushang Desai
22 Manganese 149
Alex Lebeau
23 Mercury 157
Frank D. Stephen
24 Molybdenum 167
Paul Jonmaire
25 Nickel 173
Robyn L. Prueitt and Julie E. Goodman
26 Tantalum and Niobium 183
Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187
Alex Lebeau
28 Platinum 193
Alex Lebeau
29 Rare Earth Metals 199
Raymond D. Harbison and David R. Johnson
30 Selenium and its Compounds 205
Anna M. Fan and Marco Vinceti
31 Silver 229
Giffe T. Johnson
32 Tellurium 233
Marek Banasik
33 Thallium 239
Nikolay M. Filipov
34 Tin 247
Raymond D. Harbison and David R. Johnson
35 Titanium 253
Ushang Desai and Raymond D. Harbison
36 Tungsten 257
Kambria K. Haire and Raymond D. Harbison
37 Vanadium 261
James C. Ball and Maureen R. Gwinn
38 Zinc 277
Giffe T. Johnson
39 Hafnium and Zirconium 283
Kambria K. Haire, Jayme P. Coyle, and Raymond D. Harbison
40 Metal Fume Fever and Metal-Related Lung Disease 289
Thomas Truncale
Section III Chemical Compounds I 301
Section Editor: Raymond D. Harbison
41 Introduction 303
Raymond D. Harbison
42 Carbon Dioxide 305
Debra J. Price
43 Carbon Monoxide 309
Erin L. Pulster and James V. Hillman
44 Carbon Disulfide 317
Debra J. Price
45 Hydrogen Sulfide 325
Stephen C. Harbison and Jacob R. Bourgeois
46 Cyanide 331
Erin L. Pulster and James V. Hillman
47 Halogens 341
Joseph A. Puccio
48 Phosgene 357
Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto
49 Nitrogen Compounds 363
Kathleen T. Jenkins
50 Oxygen and Ozone 371
Robert A. Klocke
51 Phosphorus Compounds 383
M. Rony Francois and Frank Stephen
52 Sulfur Compounds 391
Frank Stephen and M. Rony Francois
Section IV Organic Compounds 401
Section Editor: Raymond D. Harbison
53 Aliphatic Hydrocarbons 403
Mayowa Amosu, Nicole Nation, and Mary Alice Smith
54 Alcohols and Glycols 419
Kelly W. Hall
55 Aldehydes and Ketones 445
Jason S. Garcia and Raymond D. Harbison
56 Ethers and Epoxides 491
Erin L. Pulster, Jacob R. Bourgeois, and Raymond D. Harbison
57 Esters 505
Raymond D. Harbison and C. Clifford Conaway
58 Chlorinated Hydrocarbons 541
Michael H. Lumpkin
59 Other Halogenated Hydrocarbons 567
Michael H. Lumpkin
60 Aromatic Hydrocarbons 581
Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson, and Marie M.
Bourgeois
61 Amino and Nitro Compounds 615
David Y. Lai and Yin-Tak Woo
62 Methyl Tert-Butyl Ether (MTBE) 643
Janice S. Lee and Robyn Blain
63 Ethyl Tertiary Butyl Ether (ETBE) 651
Keith D. Salazar
64 tert-Butyl Alcohol 657
Janice S. Lee
65 Naphthalene 663
Lisa A. Bailey, Laura E. Kerper, and Lorenz R. Rhomberg
66 Gasoline (Petrol, Motor Spirits, Motor Fuel, Natural Gasoline, Benzin,
Mogas) 669
Raymond D. Harbison and Daniel A. Newfang
67 1-Bromopropane 677
Marek Banasik
68 Diacetyl 683
David J. Hewitt
69 Perfluoroalkyl Compounds 689
Jason S. Garcia and Raymond D. Harbison
70 Tetrahydrofuran 719
Ghazi A. Dannan
71 Perchloroethylene (Tetrachloroethylene) 727
David G. Dodge and Julie E. Goodman
72 Trichloroethylene 733
David G. Dodge and Julie E. Goodman
73 Acrylonitrile 741
Jason M. Fritz and April M. Luke
Section V Organic High Polymers, Monomers, and Polymer Additives 755
Section Editor: Raymond D. Harbison
74 Introduction 757
Raymond D. Harbison
75 Plastics 759
Marek Banasik
76 Elastomers 785
Marek Banasik
77 Synthetic Fibers 791
Marek Banasik
78 Bisphenol A (4,4¿-Isopropylidenediphenol) 795
Julie E. Goodman, Lorenz R. Rhomberg, and Michael K. Peterson
79 Polystyrene/Styrene 809
Leslie A. Beyer and Julie E. Goodman
80 Phthalates 815
Robert W. Benson
81 Decabromodiphenyl Ethane 821
Marek Banasik
82 Tetrabromobisphenol A 827
David Y. Lai
83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik
84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845
Marek Banasik
Section VI Pesticides 855
Section Editor: Raymond D. Harbison
85 Introduction 857
Raymond D. Harbison
86 Insecticides 859
Carol S. Wood
87 Herbicides 877
Giffe T. Johnson
88 Fungicides 901
Amora Mayo-Perez and Raymond D. Harbison
89 Rodenticides 917
Daniel L. Sudakin
Section VII Dusts and Fibers 927
Section Editor: Raymond D. Harbison
90 Introduction 929
David R. Johnson
91 Benign Dusts (Nuisance Dusts) 931
Humairat H. Rahman and Raymond D. Harbison
92 Fibrogenic Dusts 935
Charles Barton
93 Mixed Dusts 949
Charles Barton
94 Synthetic Vitreous Fibers 959
Thomas Truncale and Yehia Y. Hammad
95 Organic Dusts 969
David R. Johnson
96 Naturally Occurring Mineral Fibers 997
Ali K. Hamade, Christopher M. Long, and Peter A. Valberg
97 Nanoparticles 1025
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section VIII Physical Agents 1029
Section Editor: Marie Bourgeois
98 Radio-Frequency Radiation 1031
R. Timothy Hitchcock
99 Optical Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045
Joseph M. Greco
100 Ionizing Radiation 1055
Thomas A. Lewandowski, Juhi K. Chandalia, and Peter A. Valberg
101 Electromagnetic Waves (EMF and RF) and Health Effects 1069
Peter A. Valberg
102 Traumatogens Associated with Carpal Tunnel Syndrome 1087
Joan M. Watkins
103 Vibration 1099
Donald E. Wasserman
104 Occupational Noise 1115
David L. Dahlstrom
105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson
Section IX Special Topics 1129
Section Editor: Raymond D. Harbison
106 Mode of Action/Human Relevance Framework 1131
M.E. (Bette) Meek
107 Carcinogenesis 1135
Carlos A. Muro-Cacho
108 Genotoxicity Testing Strategies, Guidelines, and Methods 1173
Ching-hung Hsu and Qingli Wang
109 Human Relevance of Rodent Leydig Cell Tumors 1189
Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F. Hardisty
110 Reproductive Toxicology 1197
Judith W. Henck
111 Developmental Toxicology 1229
Thomas A. Lewandowski
112 Ototoxicity 1241
Matthew Mifsud and K. Paul Boyev
113 Dermal and Ocular Toxicity 1247
Jayme P. Coyle, Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois,
and Raymond D. Harbison
114 Reactive Airways Dysfunction Syndrome (RADS) 1259
David J. Hewitt
115 Pulmonary Sensitization 1263
David J. Hewitt
116 "Street" and Prescription Drug Abuse 1267
Sharon S. Kelley, James Godin, and John Christie
117 Mycotoxins 1283
Clara Y. Chan and Bruce J. Kelman
118 Phosphine 1295
Michael W. Perkins, Benjamin Wong, Dorian Olivera, and Alfred Sciuto
119 Diesel Exhaust 1301
J. Michael Berg, Phillip T. Goad, and Thomas W. Hesterberg
120 Spaceflight Operations 1311
Michael A. Cardinale, Philip J. Scarpa, James R. Taffer, and Daniel Woodard
121 Regulatory Toxicology 1321
David M. Polanic and Marek Banasik
Index 1331
Abbreviations xvii
The Heritage of Alice Hamilton MD and Harriet Hardy MD xix
In Memory xxi
Preface xxiii
Section I Introduction 1
Section Editor: Raymond D. Harbison
1 The Modern Approach to the Diagnosis of Occupational Disease 3
Raymond D. Harbison and Jeffrey H. Mandel
2 Controls of Occupational Diseases 13
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section II Metals and Metalloids 19
Section Editor: Richard V. Lee
3 Introduction 21
Richard V. Lee
4 Alkali Compounds 25
Steve Morris and Ann Lurati
5 Aluminum 33
Giffe T. Johnson
6 Antimony 39
Marie M. Bourgeois
7 Arsenic 45
Janice S. Lee and Santhini Ramasamy
8 Barium 57
Marie M. Bourgeois
9 Beryllium 63
Alison J. Abritis and Raymond D. Harbison
10 Bismuth and Related Compounds 73
Paul Jonmaire
11 Boron 79
Giffe T. Johnson
12 Cadmium 85
Frank D. Stephen
13 Chromium 95
Kathleen Macmahon
14 Cobalt 101
Davinderjit Singh and Raymond D. Harbison
15 Copper 109
Marie M. Bourgeois
16 Gallium and Indium 115
Jayme P. Coyle and Raymond D. Harbison
17 Germanium 119
Marek Banasik
18 Gold 123
Marek Banasik
19 Iron 127
Steve Morris and Jayme P. Coyle
20 Lead 131
Frank D. Stephen
21 Lithium 141
Ushang Desai
22 Manganese 149
Alex Lebeau
23 Mercury 157
Frank D. Stephen
24 Molybdenum 167
Paul Jonmaire
25 Nickel 173
Robyn L. Prueitt and Julie E. Goodman
26 Tantalum and Niobium 183
Jayme P. Coyle and Raymond D. Harbison
27 Platinum Group Elements: Palladium, Iridium, Osmium, Rhodium, and
Ruthenium 187
Alex Lebeau
28 Platinum 193
Alex Lebeau
29 Rare Earth Metals 199
Raymond D. Harbison and David R. Johnson
30 Selenium and its Compounds 205
Anna M. Fan and Marco Vinceti
31 Silver 229
Giffe T. Johnson
32 Tellurium 233
Marek Banasik
33 Thallium 239
Nikolay M. Filipov
34 Tin 247
Raymond D. Harbison and David R. Johnson
35 Titanium 253
Ushang Desai and Raymond D. Harbison
36 Tungsten 257
Kambria K. Haire and Raymond D. Harbison
37 Vanadium 261
James C. Ball and Maureen R. Gwinn
38 Zinc 277
Giffe T. Johnson
39 Hafnium and Zirconium 283
Kambria K. Haire, Jayme P. Coyle, and Raymond D. Harbison
40 Metal Fume Fever and Metal-Related Lung Disease 289
Thomas Truncale
Section III Chemical Compounds I 301
Section Editor: Raymond D. Harbison
41 Introduction 303
Raymond D. Harbison
42 Carbon Dioxide 305
Debra J. Price
43 Carbon Monoxide 309
Erin L. Pulster and James V. Hillman
44 Carbon Disulfide 317
Debra J. Price
45 Hydrogen Sulfide 325
Stephen C. Harbison and Jacob R. Bourgeois
46 Cyanide 331
Erin L. Pulster and James V. Hillman
47 Halogens 341
Joseph A. Puccio
48 Phosgene 357
Benjamin Wong, Michael W. Perkins, and Alfred M. Sciuto
49 Nitrogen Compounds 363
Kathleen T. Jenkins
50 Oxygen and Ozone 371
Robert A. Klocke
51 Phosphorus Compounds 383
M. Rony Francois and Frank Stephen
52 Sulfur Compounds 391
Frank Stephen and M. Rony Francois
Section IV Organic Compounds 401
Section Editor: Raymond D. Harbison
53 Aliphatic Hydrocarbons 403
Mayowa Amosu, Nicole Nation, and Mary Alice Smith
54 Alcohols and Glycols 419
Kelly W. Hall
55 Aldehydes and Ketones 445
Jason S. Garcia and Raymond D. Harbison
56 Ethers and Epoxides 491
Erin L. Pulster, Jacob R. Bourgeois, and Raymond D. Harbison
57 Esters 505
Raymond D. Harbison and C. Clifford Conaway
58 Chlorinated Hydrocarbons 541
Michael H. Lumpkin
59 Other Halogenated Hydrocarbons 567
Michael H. Lumpkin
60 Aromatic Hydrocarbons 581
Raymond D. Harbison, Amora Mayo-Perez, David R. Johnson, and Marie M.
Bourgeois
61 Amino and Nitro Compounds 615
David Y. Lai and Yin-Tak Woo
62 Methyl Tert-Butyl Ether (MTBE) 643
Janice S. Lee and Robyn Blain
63 Ethyl Tertiary Butyl Ether (ETBE) 651
Keith D. Salazar
64 tert-Butyl Alcohol 657
Janice S. Lee
65 Naphthalene 663
Lisa A. Bailey, Laura E. Kerper, and Lorenz R. Rhomberg
66 Gasoline (Petrol, Motor Spirits, Motor Fuel, Natural Gasoline, Benzin,
Mogas) 669
Raymond D. Harbison and Daniel A. Newfang
67 1-Bromopropane 677
Marek Banasik
68 Diacetyl 683
David J. Hewitt
69 Perfluoroalkyl Compounds 689
Jason S. Garcia and Raymond D. Harbison
70 Tetrahydrofuran 719
Ghazi A. Dannan
71 Perchloroethylene (Tetrachloroethylene) 727
David G. Dodge and Julie E. Goodman
72 Trichloroethylene 733
David G. Dodge and Julie E. Goodman
73 Acrylonitrile 741
Jason M. Fritz and April M. Luke
Section V Organic High Polymers, Monomers, and Polymer Additives 755
Section Editor: Raymond D. Harbison
74 Introduction 757
Raymond D. Harbison
75 Plastics 759
Marek Banasik
76 Elastomers 785
Marek Banasik
77 Synthetic Fibers 791
Marek Banasik
78 Bisphenol A (4,4¿-Isopropylidenediphenol) 795
Julie E. Goodman, Lorenz R. Rhomberg, and Michael K. Peterson
79 Polystyrene/Styrene 809
Leslie A. Beyer and Julie E. Goodman
80 Phthalates 815
Robert W. Benson
81 Decabromodiphenyl Ethane 821
Marek Banasik
82 Tetrabromobisphenol A 827
David Y. Lai
83 Tris[2-Chloro-1-(Chloromethyl)Ethyl] Phosphate (TDCPP) 837
Marek Banasik
84 Tris(2-Chloro-1-Methylethyl) Phosphate (TCPP) 845
Marek Banasik
Section VI Pesticides 855
Section Editor: Raymond D. Harbison
85 Introduction 857
Raymond D. Harbison
86 Insecticides 859
Carol S. Wood
87 Herbicides 877
Giffe T. Johnson
88 Fungicides 901
Amora Mayo-Perez and Raymond D. Harbison
89 Rodenticides 917
Daniel L. Sudakin
Section VII Dusts and Fibers 927
Section Editor: Raymond D. Harbison
90 Introduction 929
David R. Johnson
91 Benign Dusts (Nuisance Dusts) 931
Humairat H. Rahman and Raymond D. Harbison
92 Fibrogenic Dusts 935
Charles Barton
93 Mixed Dusts 949
Charles Barton
94 Synthetic Vitreous Fibers 959
Thomas Truncale and Yehia Y. Hammad
95 Organic Dusts 969
David R. Johnson
96 Naturally Occurring Mineral Fibers 997
Ali K. Hamade, Christopher M. Long, and Peter A. Valberg
97 Nanoparticles 1025
Daniel A. Newfang, Giffe T. Johnson, and Raymond D. Harbison
Section VIII Physical Agents 1029
Section Editor: Marie Bourgeois
98 Radio-Frequency Radiation 1031
R. Timothy Hitchcock
99 Optical Radiation: Ultraviolet, Visible Light, Infrared, and Lasers 1045
Joseph M. Greco
100 Ionizing Radiation 1055
Thomas A. Lewandowski, Juhi K. Chandalia, and Peter A. Valberg
101 Electromagnetic Waves (EMF and RF) and Health Effects 1069
Peter A. Valberg
102 Traumatogens Associated with Carpal Tunnel Syndrome 1087
Joan M. Watkins
103 Vibration 1099
Donald E. Wasserman
104 Occupational Noise 1115
David L. Dahlstrom
105 Heat Stress Illness 1123
Marie M. Bourgeois and David R. Johnson
Section IX Special Topics 1129
Section Editor: Raymond D. Harbison
106 Mode of Action/Human Relevance Framework 1131
M.E. (Bette) Meek
107 Carcinogenesis 1135
Carlos A. Muro-Cacho
108 Genotoxicity Testing Strategies, Guidelines, and Methods 1173
Ching-hung Hsu and Qingli Wang
109 Human Relevance of Rodent Leydig Cell Tumors 1189
Thomas J. Steinbach, Robert. R. Maronpot, and Jerry F. Hardisty
110 Reproductive Toxicology 1197
Judith W. Henck
111 Developmental Toxicology 1229
Thomas A. Lewandowski
112 Ototoxicity 1241
Matthew Mifsud and K. Paul Boyev
113 Dermal and Ocular Toxicity 1247
Jayme P. Coyle, Alison J. Abritis, Amora Mayo-Perez, Marie M. Bourgeois,
and Raymond D. Harbison
114 Reactive Airways Dysfunction Syndrome (RADS) 1259
David J. Hewitt
115 Pulmonary Sensitization 1263
David J. Hewitt
116 "Street" and Prescription Drug Abuse 1267
Sharon S. Kelley, James Godin, and John Christie
117 Mycotoxins 1283
Clara Y. Chan and Bruce J. Kelman
118 Phosphine 1295
Michael W. Perkins, Benjamin Wong, Dorian Olivera, and Alfred Sciuto
119 Diesel Exhaust 1301
J. Michael Berg, Phillip T. Goad, and Thomas W. Hesterberg
120 Spaceflight Operations 1311
Michael A. Cardinale, Philip J. Scarpa, James R. Taffer, and Daniel Woodard
121 Regulatory Toxicology 1321
David M. Polanic and Marek Banasik
Index 1331