The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug…mehr
The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation.
Protein Kinases in Drug Discovery: Rationale, Success, and Challenge. An Introduction to the Protein Tyrosine Phosphatase Gene Family and Screening Assay Development. Time-Resolved Fluorescence and Time-Resolved Fluorescence Resonance Energy Transfer. Developement of High-Thoroughput Screening Assays for Kinase Drug Targets using AlphaScreen Technology. Homogeneous HTS Assays for Serine/Threonine Kinases using b-galactosidase Enzyme Fragment Complementation. IMAP Assays for Assaying Protein Kinases. A Homogeneous, Luminescent, High Throughput, and Versatile Assay for Wide Range of Kinases. Proteases as Drug Targets. Comparison of Homogeneous Bioluminescent and Fluorescent Methods for Protease Assays. SPA Receptor Binding Assays. Radioligand Binding Filtration Assay: Full Automation. Nuclear Receptors as Drug Targets. Nuclear Receptor Scintillation Proximity Assays. Homogeneous Assay Development for Nuclear Receptor using the AlphaScreen Technology. Development of Nuclear Receptor Homogeneous Assay using the Lance Technology. Emerging Role of Cell-based Assays in Discovery. The Preparation of Cells for High Content Screening. The Evolution of cAMP Assays. A Homogeneous Fluorescent Polarization Assay for Inositol 1, 4, 5 Trisphosphate (Ins P3). Scintillation Proximity Assay of Inositol Phosphates. Measuring Calcium Mobilization with Gq-Coupled GPCRs using the Fluorometric Imaging Plate Reader (FLIPR). Development of FLIPR-Based HTS Assay for Gi Coupled GPCRs. Aurora Assays. Membrane Potential Based Assays for Ion Channels and Electrogenic Transporters.
Protein Kinases in Drug Discovery: Rationale, Success, and Challenge. An Introduction to the Protein Tyrosine Phosphatase Gene Family and Screening Assay Development. Time-Resolved Fluorescence and Time-Resolved Fluorescence Resonance Energy Transfer. Developement of High-Thoroughput Screening Assays for Kinase Drug Targets using AlphaScreen Technology. Homogeneous HTS Assays for Serine/Threonine Kinases using b-galactosidase Enzyme Fragment Complementation. IMAP Assays for Assaying Protein Kinases. A Homogeneous, Luminescent, High Throughput, and Versatile Assay for Wide Range of Kinases. Proteases as Drug Targets. Comparison of Homogeneous Bioluminescent and Fluorescent Methods for Protease Assays. SPA Receptor Binding Assays. Radioligand Binding Filtration Assay: Full Automation. Nuclear Receptors as Drug Targets. Nuclear Receptor Scintillation Proximity Assays. Homogeneous Assay Development for Nuclear Receptor using the AlphaScreen Technology. Development of Nuclear Receptor Homogeneous Assay using the Lance Technology. Emerging Role of Cell-based Assays in Discovery. The Preparation of Cells for High Content Screening. The Evolution of cAMP Assays. A Homogeneous Fluorescent Polarization Assay for Inositol 1, 4, 5 Trisphosphate (Ins P3). Scintillation Proximity Assay of Inositol Phosphates. Measuring Calcium Mobilization with Gq-Coupled GPCRs using the Fluorometric Imaging Plate Reader (FLIPR). Development of FLIPR-Based HTS Assay for Gi Coupled GPCRs. Aurora Assays. Membrane Potential Based Assays for Ion Channels and Electrogenic Transporters.
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