E.P. Riley / C.V. Vorhees (eds.)

Handbook of Behavioral Teratology

Herausgegeben von Riley, E.P.; Vorhees, C.V.

• Gebundenes Buch

Produktbeschreibung

This book was developed in response to a need in behavioral teratology for a comprehen­ sive set of reviews of the field's many topics brought together in a single source. This volume represents the first effort to synthesize and integrate research in the field since 1969 when Justin Joffe wrote Prenatal Determinants of Behaviour. Joffe's book became a standard reference for many years, particularly for the experimental design of animal investigations. It has become increasingly evident, however, that some aspects of design once considered inviolate have changed and become part of a more flexible approach. In current research the emphasis is on a set of prioritized, but focused, experimental ques­ tions rather than on designs which factor all possible variables into every experiment. Also, new design considerations have arisen over the last 15 years, not appreciated when Joffe wrote. Moreover, the sheer volume of new experimental evidence generated since 1969 has increased the content of the field several fold. These considerations made a new review and critical appraisal of the field compelling. The book is divided into four major sections. Part I contains four chapters. These chapters provide discussions of the general principles of behavioral teratogenesis, and information on the historical, governmental, and methodological contexts in which the field operates. The purpose of these chapters is to provide the framework within which the review chapters in the remainder of the book may best be understood.

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Produktdetails

• Verlag: Springer, Berlin
• 1986.
• Seitenzahl: 542
• Erscheinungstermin: 30. November 1986
• Englisch
• Gewicht: 1060g
• ISBN-13: 9780306422461
• ISBN-10: 0306422468
• Artikelnr.: 24469232

Inhaltsangabe

I General Principles and Issues.- 1 · Origins of Behavioral Teratology.- 1. Introduction.- 2. Emergence of Behavioral Teratology.- 3. Reemergence of Behavioral Teratology.- 4. Behavioral Teratology and Behavioral Toxicology.- 5. The Prenatal/Postnatal Dichotomy.- 6. Dual Influence of Regulations and the Fetal Alcohol Syndrome.- 6.1. Influence of Government Regulations.- 6.2. Influence of Discovery of the Fetal Alcohol Syndrome.- 7. Collaborative Project on Behavioral Teratology Methods.- 8. Other Influences.- 9. Scope of the Problem, or Who Cares Anyway?.- 10. Concluding Remarks.- 11. References.- 2 · Principles of Behavioral Teratology.- 1. Introduction.- 2. Wilson s Principles of Teratology.- 2.1. Principle of Genetic and Environmental Determination.- 2.2. Principle of Critical Periods.- 2.3. Principle of Specific Mechanisms.- 2.4. Principle of Teratogenic Response.- 2.5. Principle of Target Access.- 2.6. Principle of Dose-Response Relationships.- 3. Principles of Behavioral Teratology.- 3.1. Principle of Genetic Determination.- 3.2. Principle of Critical Periods.- 3.3. Principle of Specific Mechanisms.- 3.4. Principle of Behavioral Teratogenic Response.- 3.5. Principle of Target Access.- 3.6. Principle of Dose-Response Relationships.- 3.7. Principle of Environmental Determination.- 3.8. Principle of Types of Behavioral Teratogens.- 3.9. Principle of Response Relationships.- 3.10. Principle of Maximum Susceptibility.- 3.11. Principle of Limits of Behavioral Teratogenic Susceptibility.- 3.12. Principle of Preconceptional and Transgenerational Effects.- 4. Behavioral versus Physical Teratogenesis.- 5. Concluding Remarks.- 6. References.- 3 · Comparison and Critique of Government Relations for Behavioral Teratology.- 1. Introduction.- 1.1. The Mandate.- 1.2. A Comparison.- 1.3. Logic or Fallacy?.- 2. Description and Critique of Regulations in Japan.- 3. Description and Critique of Regulations in Great Britain.- 4. Description and Critique of Regulations in France and Italy.- 5. Regulations of the European Economic Community.- 6. Summary of the Critique of Existing Guidelines.- 7. Description and Critique of Regulations in the United States.- 7.1. Overview.- 7.2. Food and Drug Administration Guidelines.- 7.3. Environmental Protection Agency Guidelines.- 8. Conclusions.- 9. References.- 4 · Methods in Behavioral Teratology.- 1. Introduction.- 2. General Experimental Design: Considerations for Increasing the Sensitivity of the Experiment.- 2.1. Procedures for the Reduction of Error Variance.- 2.2. Determination of the Appropriate Sample Size for Postnatal Testing.- 2.3. The Use of a Replicate Design.- 3. Guidelines for the Selection of Methods.- 3.1. When Human Behavioral Teratology Data Are Available.- 3.2. When Neurochemical, Neuroanatomical, or Animal Behavioral Data Are Available.- 3.3. When Information Is Not Available.- 4. Glossary of Methods That Are Frequently Used in Behavioral Teratology Studies.- 4.1. Measures of Learning Abilities.- 4.2. Measures of Sensory Function.- 4.3. Measures of Activity.- 4.4. Measures of Pharmacological Responsiveness.- 4.5. Measures of Neuromotor Abilities.- 5. Interpretation of Results.- 6. References.- II Drugs.- 5 · Behavioral Teratology of Alcohol.- 1. Introduction.- 2. Procedural Considerations.- 3. Behavioral Effects of Prenatal Alcohol Exposure.- 3.1. Suckling Behavior.- 3.2. Developmental Indices.- 3.3. Activity and Exploration.- 3.4. Learning.- 3.5. Sexually Dimorphic Behaviors.- 3.6. Aggression.- 3.7. Ethanol Preference, Sensitivity, and Tolerance.- 3.8. Reactivity and Seizure Susceptibility.- 4. Psychopharmacological Aspects of Behavioral Dysfunctions.- 5. Organizing Theories and Mechanisms.- 6. Summary.- 7. References.- 6 · Neurobehavioral Effects in Human and Animal Offspring following Prenatal Exposure to Methadone.- 1. Introduction.- 2. Neurobehavioral Effects in Infants and Children.- 2.1. Neonatal Sleep Studies.- 2.2. The Neonatal Abstinence Syndrome.- 2.3. Abstinence Me