Hazardous Reagent Substitution

A Pharmaceutical Perspective
Herausgeber: Sharma, Rakesh Kumar; Bandichhor, Rakeshwar

• Gebundenes Buch

Produktbeschreibung

In recent years, a significant amount of progress has been made using green chemistry in the synthesis of synthetically useful compounds and molecules by replacing hazardous chemicals with greener alternatives. However, there is still room for improvement, especially in the pharmaceutical sector where new drugs are being formulated. This book examines green approaches to overcoming hazardous organic transformations. Summarizing recent developments, the book features a detailed description of some of the high impact active pharmaceutical ingredients that have been developed considering green chemistry approaches. It explores the design, engineering and process development and the calculations to account for waste. The book includes strategies to further advance green approaches in the development of generic pharmaceutical industries and features novel, innovative approaches that promote waste-free organic synthesis. This book is of interest to industrialists working in pharmaceuticals and researchers working in green chemistry.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 194
• Erscheinungstermin: 12. Dezember 2017
• Englisch
• Abmessung: 234mm x 163mm x 18mm
• Gewicht: 454g
• ISBN-13: 9781782620501
• ISBN-10: 1782620508
• Artikelnr.: 49009945

Inhaltsangabe

Introduction to Hazardous Reagent Substitution in the Pharmaceutical Industry
Recyclability of Reagents
Recoverable Polymer-supported DMAP Derivatives
Synthesis of Atorvastatin
Synthesis of Raloxifene
Synthesis of Montelukast
Development of a Safe, Scalable, Azide-free Synthesis of 1-Aryl-1H-tetrazoles Using Diformylhydrazine
New Directions from Academia