Renal transplantation is the golden method for management of end-stage renal disease.The new onset of diabetes mellitus [DM] after kidney transplantion has been linked to higher rates of cardiovascular disease and infection, and it is a major cause of morbidity and mortality . DM has been reported among renal transplant patients with chronic hepatitis C virus [HCV] infection. However, the association is controversial. This work aimed to study the impact of HCV on the development of DM among Egyptian live-donor renal allo-transplant recipients. This retrospective single Center study included 913 kidney transplant recipients who were transplanted at Mansoura urology & nephrology Centre between 2000& 2010, the patients divided into four groups according to their HCV serology and diabetic status.