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The result of the present study shows that the administration of DADS has significant antiperoxidative effect against induced HgCl2 toxicity. The protective effect of DADS in HgCl2 induced rats may be due to the antioxidant and anticancer effect of DADS It has been suggested that the number of sulfur atoms and allyl groups may play a determining factor on the biological activities of garlic organosulfur compounds