Evaluating the body's adaptive capacity in people who are in states that border between health and disease is extremely difficult. Left ventricular myocardial hypertrophy (LVH) of the heart, changes in the geometry of the heart muscle (remodeling) is one of the most frequent and early compensatory mechanisms in response to increased volume or resistance load. Progressive myocardial hypertrophy becomes an aggravating factor for heart activity. Cardiovascular diseases are widespread in the population, which are the main cause of adaptive myocardial hypertrophy of the left ventricle - coronary heart disease, arterial hypertension. The authors present the results of the study of morphofunctional condition and the level of adaptation of the cardiovascular system in healthy men of working age and men with cardiovascular pathology according to clinical and instrumental analysis. The significance of the formed myocardial hypertrophy of the left ventricle was assessed from the point of view of the adaptation theory and new LVL markers were revealed based on the electrocardiography data in comparison with echocardiography.