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Heat stroke is a critical medical emergency characterized by a rapid rise in core temperature above 40°C, accompanied by neurological and cardiovascular disorders. This condition can lead to Multi-Visceral Failure Syndrome and potentially death.Our descriptive cross-sectional study included 27 heatstroke victims, taken into pre-hospital care by the SAMU of central-eastern Tunisia, over three months June-August 2023.92.6% of patients benefited from physical cooling and 70.3% from pharmacological cooling. Oral hydration was administered to 48.1% and 85.1% received cooled serum filling. Vasoactive drugs were required in 11.1% of patients. Oxygen therapy was delivered to 48.1%, with mechanical ventilation used for 22.2%.33.3% of patients died, while 66.7% improved.Predictive factors for mortality included elevated core temperature, confusion, coma, visceral compromise, hemodynamic distress, use of mechanical ventilation, administration of vasoactive drugs No significant difference for cooling...