Life on this planet has evolved in the presence of metals. Metals have been mined and used since ancient times. Cells learned to make use of the more abundant metals in the Archean oceans at an integral component in their structure and function.Living cells need metals as micro molecules to do their biochemical functions. From the elements discovered so far few are essential, some are useful whereas few show adverse effects on living organisms. Those which are useful required in very minute amount and their higher concentration cause harm or pose adverse effects on living forms.