The book documents the physical-chemical distribution of heavy metal in biotic and abiotic components with reference to hydrological characteristics of East Berbice-Corentyne Coast, Guyana. Besides heavy metal concentrations increased in water and sediment samples of the polluted sites. It also provide information on the bioaccumulation of heavy metals and its associated histopathological perturbations were studied in various tissues of M. cephalus collected from polluted and compared with the fish collected from less polluted of Corentyne coast. The presence of large lipid droplets in liver and increase of mucous cell in gill were some of the most noticeable alterations observed and were related to heavy metal contaminates. It is concluded that histopathological and ultrastructural biomarkers provide reliable and discriminatory data to augment heavy metal pollution in polluted site of Coretyne coast. Based on the present study, heavy metal accumulation in the biotic and abiotic components to displayed on alarming trend and hence it needs to be protected from pollution and also from other environmental risks.