Hedgehog signaling activation in human cancer and its clinical implications

Herausgegeben:Xie, Jingwu

• Broschiertes Buch

Produktbeschreibung

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4899-9541-4
• 2011
• Seitenzahl: 228
• Erscheinungstermin: 1. Oktober 2014
• Englisch
• Abmessung: 235mm x 155mm x 13mm
• Gewicht: 355g
• ISBN-13: 9781489995414
• ISBN-10: 1489995412
• Artikelnr.: 41623248

Inhaltsangabe

Chapter 1- Overview of hedgehog signaling pathway

Chi-chung Hui and Jin Jiang

Chapter 2- Regulation of Hh morphogene gradient

G. D'Angelo, F. Wendler, K. Ayers and P.P. Thérond

Chapter 3- Smoothened Signaling through a G-protein Effector Network

David J. Robbins and Stacey K. Ogden

Chapter 4- Kinases and phosphatases in hedgehog signaling

Jianhang Jia

Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer

Xiaodong Cheng

Chapter 6- Crosstalks between PKC and hedgehog signaling

Jing Li and Mark Evers

Chapter 7- Activation of Hh signaling in human cancer

Jingwu Xie and Ervin Epstein

Chapter 8- Hedgehog signaling in pediatric brain tumors

Joon Won Yoon, Ph.D., Jason Fangusaro, M.D., Philip Iannaccone, M.D., Ph.D., and David Walterhouse, M.D.

Chapter 9- Hedgehog Signaling in Mammary Gland Development and Breast Cancer

Adriana P. Visbal and Michael T. Lewis

Chapter 10- Hedgehog signaling and cancer therapeutic resistance

K.S. Clifford Chao and Yu-Jen Chen

Chapter 11- Small-molecule Inhibitors of the Hedgehog Pathway

Ari J. Firestone and James K. Chen

Chapter 12- Cyclopamine and its derivatives for cancer therapeutics

Martin Tremblay and Karen McGovern