Hedgehog signaling activation in human cancer and its clinical implications

Herausgegeben:Xie, Jingwu

• Broschiertes Buch

Produktbeschreibung

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4899-9541-4
• 2011
• Seitenzahl: 228
• Erscheinungstermin: 1. Oktober 2014
• Englisch
• Abmessung: 235mm x 155mm x 13mm
• Gewicht: 355g
• ISBN-13: 9781489995414
• ISBN-10: 1489995412
• Artikelnr.: 41623248

Inhaltsangabe

Overview of hedgehog signaling pathway.- Regulation of Hh morphogene gradient.- Smoothened Signaling through a G-protein Effector Network.- Kinases and phosphatases in hedgehog signaling.- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer.- Crosstalks between PKC and hedgehog signaling.- Activation of Hh signaling in human cancer.- Hedgehog signaling in pediatric brain tumors.- Hedgehog Signaling in Mammary Gland Development and Breast Cancer.- Hedgehog signaling and cancer therapeutic resistance.- Small-molecule Inhibitors of the Hedgehog Pathway.- Cyclopamine and its derivatives for cancer therapeutics.-