Diseases that affect all three hematopoietic lines fall under the hematologist's care burden. Almost romantically, the study and clinical approach to hematologic malignancies becomes the focus of attention for many physicians in the specialty. The present material proposes a particular approach to myeloproliferative neoplasms, lymphomas and monoclonal gammopathies. It systematizes clinical, epidemiological and laboratory variables that have characterized adult patients diagnosed with these entities during the last ten years in the Oncohematology service of the General Teaching Hospital "Comandante Pinares" in the Cuban province of Artemisa. Let this work serve as a testimony of the effort made to guarantee the health of our patients, as well as an academic and scientific complement for the training of new general practitioners and specialists.