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Hematopoietic stem cell (HSC) defined by their ability to self-renewal and differentiation to all blood cell types in hematological system during the organism entire life time. Multi-potent stromal cells and their osteoblastic lineage cell are part of the bone marrow (BM) niche and contribute to HSC maintenance In the leukemia process, a large and diverse group of genetic and environmental variables have been proposed resulting in normal hematopoiesis impairing and favors leukemic stem cell(LSC) function which gradually go to BM niche remodeling. Thus, we try to expand our understanding on the…mehr

Produktbeschreibung
Hematopoietic stem cell (HSC) defined by their ability to self-renewal and differentiation to all blood cell types in hematological system during the organism entire life time. Multi-potent stromal cells and their osteoblastic lineage cell are part of the bone marrow (BM) niche and contribute to HSC maintenance In the leukemia process, a large and diverse group of genetic and environmental variables have been proposed resulting in normal hematopoiesis impairing and favors leukemic stem cell(LSC) function which gradually go to BM niche remodeling. Thus, we try to expand our understanding on the leukemic hematopoiesis effects in the BM microenvironment and how leukemic hematopoiesis disrupts normal mechanisms.
Autorenporträt
Ahmad Reza Rahnemoon fue miembro académico de la Universidad de Ciencias Médicas de Irán (IUMS), ahora jubilado en el departamento de hematología de la IUMS. Tiene experiencia sobre todo en el microambiente hematopoyético, algunos genes de fusión en la leucemia, la anemia aplástica y el síndrome mielodisplásico. Ha publicado artículos y presentado ponencias en varios congresos europeos.