Donald Metcalf, Nicos Anthony Nicola

Hemopoietic Colony-Stimulating Factors

From Biology to Clinical Applications

• Gebundenes Buch

Produktbeschreibung

This book provides a detailed and up-to-date account of the discovery of the CSFs, their structure, molecular biology, and cellular receptors, the biology of the CSFs in vivo and in vitro, and their present and possible future clinical applications. Written by two of the pioneers in the discovery of the CSFs, it is a clear and well-illustrated survey of the history, current knowledge, and future directions of this exciting field of investigation, and also serves as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care.

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Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 354
• Erscheinungstermin: 13. August 2014
• Englisch
• Abmessung: 235mm x 157mm x 24mm
• Gewicht: 664g
• ISBN-13: 9780521461580
• ISBN-10: 0521461588
• Artikelnr.: 22127684

Inhaltsangabe

Preface
1. Historical introduction
2. General introduction to hemopoiesis
3. Key techniques in analyzing hemopoiesis
4. Biochemistry of the colony-stimulating factors
5. Biochemistry of the colony-stimulating factor receptors
6. Molecular genetics of the colony-stimulating factors and their receptors
7. Biological actions of the colony-stimulating factors in vitro
8. The biology of colony-stimulating factor production, degradation and clearance
9. Actions of the colony-stimulating factors in vivo
10. Role of the colony-stimulating factors in basal hemopoiesis
11. Actions of the colony-stimulating factors in resistance to infections
12. Role of the colony-stimulating factors in other disease states
13. The colony-stimulating factors and myeloid leukemia
14. Clinical uses of the colony-stimulating factors
15. Conclusions
References
Index.