Heparinase and low molecular weight heparins as antitumor agents - Nsayef Muslim, Sahira;Abd Ali AL-Kadmy, Israa M.S.;Al-Khfajy, Alaa N. Mohammed Ali
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Heparan sulfate and chondroitin sulfate, play a key role in the extracellular matrix. Heparin is an acidic polysaccharide, characterized by a disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages.Heparin is heterogeneous due to the varying degree of modification of the functional groups in the disaccharide unit. Heparin may be hydrolyzed with acid only under vigorous condition which results in considerable caramelization, especially of the glucoronic acid and extensive splitting of heparin.Thus, the product are mono(or) disaccharides from which all the sulphated groups are removed.…mehr

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Produktbeschreibung
Heparan sulfate and chondroitin sulfate, play a key role in the extracellular matrix. Heparin is an acidic polysaccharide, characterized by a disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages.Heparin is heterogeneous due to the varying degree of modification of the functional groups in the disaccharide unit. Heparin may be hydrolyzed with acid only under vigorous condition which results in considerable caramelization, especially of the glucoronic acid and extensive splitting of heparin.Thus, the product are mono(or) disaccharides from which all the sulphated groups are removed.
Autorenporträt
La dott.ssa Sahira Nsayef Muslim ha conseguito il dottorato di ricerca in Microbiologia-Biotecnologia Titolo: Studi biochimici e genetici sull'emolisina prodotta da Aeromonas hydrophila isolata da pazienti diarroici e da acque superficiali "Coll. Sci. - Università Mustansiryia - 2005.