John L. Casey (ed.)

Hepatitis Delta Virus

Herausgegeben:Casey, John

• Gebundenes Buch

Produktbeschreibung

Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently, HDV is classified as a subviral satellite of hepatitis B virus. However, unlike other satellite viruses, the dependence of HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.

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Produktdetails

• Current Topics in Microbiology and Immunology 960
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 11577317, 978-3-540-29801-4
• 2006
• Seitenzahl: 244
• Erscheinungstermin: 9. Mai 2006
• Englisch
• Abmessung: 241mm x 160mm x 20mm
• Gewicht: 478g
• ISBN-13: 9783540298014
• ISBN-10: 3540298010
• Artikelnr.: 15204561

Autorenporträt

John L. Casey, Georgetown University, Washington, DC, USA

Inhaltsangabe

Structure and Replication of Hepatitis Delta Virus RNA.- HDV RNA Replication: Ancient Relic or Primer?.- HDV Ribozymes.- RNA Editing in Hepatitis Delta Virus.- Post-translational Modification of Delta Antigen of Hepatitis D Virus.- The Role of the HBV Envelope Proteins in the HDV Replication Cycle.- Prenylation of HDAg and Antiviral Drug Development.- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?.- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection.- Immunology of HDV Infection.- The Woodchuck Model of HDV Infection.