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Hepatocellular carcinoma (HCC) is the most common liver cancer occurring in adults. It is also the leading cause of deaths in patients with liver cirrhosis. Some of the risk factors for this condition are exposure to alcohol or aflatoxin, hepatitis infection, alpha 1-antitrypsin deficiency, hemochromatosis, NASH, metabolic syndrome, etc. HCC may present symptoms such as abdominal swelling due to fluid buildup in the abdominal cavity, yellow skin, loss of appetite, easy bruising, nausea, vomiting, etc. HCC is generally diagnosed at an advanced stage and is thus associated with a high rate of mortality. CT scan, MRI and ultrasound are ideal for liver analysis and detection of HCC. The treatment of HCC is based on a review of the stage of the disease, availability of liver transplant and a person's likelihood of tolerating surgery. Accordingly, a patient may be recommended for a partial hepatectomy, orthotopic liver transplantation, targeted therapies, loco-regional therapy, etc. This book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of clinical oncology. It discusses the fundamentals as well as modern approaches in the diagnosis and treatment of this cancer. This book aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.