Hepatoprotective activity of Kamilari - Ittiyavirah, Sibi P.
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Master's Thesis from the year 2012 in the subject Pharmacology, grade: A, Mahatma Gandhi University (University College of Pharmacy), course: M.Pharm, language: English, abstract: Polyherbal formulations available with a wide range of indications like hepatoprotective , appetite and growth promoters, gastrointestinal and hepatic regulator, as treatment for hepatic dysfunction, for hepatic regeneration as well as liver stimulant and tonic. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. This study was designed to evaluate the effect of Polyherbal…mehr

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Produktbeschreibung
Master's Thesis from the year 2012 in the subject Pharmacology, grade: A, Mahatma Gandhi University (University College of Pharmacy), course: M.Pharm, language: English, abstract: Polyherbal formulations available with a wide range of indications like hepatoprotective , appetite and growth promoters, gastrointestinal and hepatic regulator, as treatment for hepatic dysfunction, for hepatic regeneration as well as liver stimulant and tonic. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. This study was designed to evaluate the effect of Polyherbal formulation Kamialri on oxidative stress and associated damages in carbon tetrachloride induced toxicity in Chang liver cells. The study is mainly focused on the evaluation of its antioxidant potential, invitro steatosis and intracellular localisation of reduced glutathione by Monochlorobimane(MCB) staining. Carbon tetrachloride induced toxicity in chang liver cells was well manifested by significant decrease in cell viability, enhanced lipid peroxidation leading to tissue damage,decreased SOD, glutathione, glutathione peroxidase and glutathione S- transferase and increased deposition of fatty acid . MTT study revealed that Kamilari has got cytoprotective activity. It has got the excellent free radical scavenging properties which was proven by various antioxidant activities (LP, SOD, GSH, GPX, and GST). Inhibitory effect of Kamilari on fatty acid deposition was proven by invitro steatosis studies which were conducted on palmitic acid treated chang cell line.Based on the above studies it is concluded that Kamilari has cytoprotective and antioxidant activity, and found to be effective in steatosis.
Autorenporträt
RESUME Dr. SIBI P IPermanent address Assistant professor in Pharmacy,Perumbamkudiyil house, Department of Pharmacology, Payyappady P. O Mahatma Gandhi University,Puthuppally, Cheruvandoorcampus, Kottayam, Kerala. Ettumanoor P. O Kottayam, Kerala. Phone: 0481-2354701 (Resi), mob: +91-9446883809 e-mail: sibitho@gmail.com Link address: http://scholar.google.co.in/citations?user=bAsPG3AAAAAJ Date of birth: 18/03/1971 Religion: Christian Caste: Jacobite Syrian Educational qualifications .PhD in Pharmacy from Delhi University in the year February 2009. .M.Pharm Specialization in Pharmacology with First Class from KLE's College of Pharmacy, Belgaum, Karnatak University, Dharwad, Karnataka in February 1996. .B.Pharm from Mangalore University, Mangalore Karnataka in May 1993. Experiences .Total of 17 years and 5 months of teaching experience after M.Pharm (Pharmacology)in M.G University, Kottayam. Publications Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats SS Agrawal, SP Ittiyavirah Immunopharmacology and immunotoxicology 32 (1), 92-982 2010 Insilico docking studies and evaluation of volatile oil of Zingiber officinale Rosc. and Aripiprazole for Antidepressant activity MP Sibi P Ittiyavirah International Journal of Genetics and Molecular Biology, pp. 88-982013 Prospective Study of Infertility in Humans due to Life Style Changes Sibi P Ittiyavirah,Chithra AR, Christy MS, Divya R Indian Journal of Pharmacy Practice 6 (3), 40-422013 Evaluation of spermicidal and antiandrogenic activities of aqueous extract of Tinospora cordifolia (Willd.) stem SP Ittiavirah, PKH Rahman African Journal of Pharmacy and Pharmacology 7 (34), 2392-23962013 In silico docking analysis of constituents of Zingiber officinale as antidepressant SP Ittiyavirah, M Paul Journal of Pharmacognosy and 5 (6), 101-1052013 Studies of Cytotoxic Potential of Cucumis melo. Linn Fruit Aqueous Extract in Prostate Cancer Cell lines PC-3 Using MTT and Neutral Red Assay SP Ittiyavirah, A George, AM Santhosh, ST Kurian, P Pappachan, G Jacob Iranian Journal of Pharmacology & Therapeutics (IJPT) 12 (1), 24-292013 Tinosporacordifolia: A Potential Plant with Immunomodulatory Activity SP Ittiyavirah, T Rahees Iranian Journal of Pharmacology & Therapeutics (IJPT) 12 (1), 30-382013 Anti stress activity of Mikania micrantha kunth roots in Wistar rats SPIS K.P Neuro Science Behav Health, 24-272013 Nootropic Studies of Ethanolic Extract of Mimosa pudica Linn. in Albino Wistar Rats SP Ittiyavirah, DP George in: American Journal of Phytomedicine and Clinical Therapeutics 1, 3, 266--2752013 Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats SP Ittiyavirah, AS Sunder Journal of Reproductive Immunology 94 (1), 522012 ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF PLUMBAGO CAPENSIS AND PLUMBAGO INDICA SP Ittiyavirah, KV Jobin, MS Jissa, M Jomy, TJ Josmi, B Littin Advances In Pharmacology And Toxicology 13 (1)2012 Antiinflamatoty and analgesic effects of Plumbago capensis and Plumbago indigo Sibi.P.Ittiyavirah, Jobin.K.V, Jisse.M.S, Johny.M Adv. Pharmacol. Toxicol., 47-522012 Comparative evaluation of aqueous extract of some selected medicinal plants for anthelmintic activity KTSMM SP Ittiyavirah, Jumimol TM Int. J. Pharmacol. Bio. Sci, 25-302012 Hormonal Effects of H2 Receptor Blockers on Implantation in Albino Wistar Rats SS Agrawal, SP Ittiyavirah International Journal of Research in Pharmaceutical and Biomedical Science, 102011 Effect of intra-uterine injection of H-2 receptor blockers on implantation in albino Wistar rats SS Agrawal, SP Ittiyavirah African Journal of Pharmacy and Pharmacology 4 (10), 735-7442010 1. ¿M.Pharm projects guided-08 in the year 2011-12.Present