Phyto-therapy clinical trial protocols for COVID-19 in Africa.Several African researchers have proposed treatment regimens to prevent or cure SARS Cov-2 infection, but few have progressed to the various phases of clinical trials. Clinical trials in Africa during the Covid-19 pandemic conflicted with treatment protocols proposed by Western researchers and Covid-19 vaccines.The emergence of local treatment protocols was a crucial response to the rise of the Covid-19 pandemic in Africa. African researchers quickly mobilized to develop treatment protocols specific to African realities. In a context where medical resources were limited, they had to be ingenious in devising appropriate solutions. They drew on the wealth of traditional medicinal plants to provide African solutions to the pandemic.