Hereditary Breast Cancer

Herausgeber: Isaacs, Claudine; Rebbeck, Timothy R.

• Gebundenes Buch

Produktbeschreibung

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 402
• Erscheinungstermin: 19. September 2007
• Englisch
• Abmessung: 260mm x 183mm x 26mm
• Gewicht: 950g
• ISBN-13: 9780849390227
• ISBN-10: 0849390222
• Artikelnr.: 22880532

Autorenporträt

Claudine Isaacs, Timothy R. Rebbeck

Inhaltsangabe

Introduction. OVERVIEW OF HEREDITARY BREAST CANCER. Genetic Epidemiology of
Hereditary Breast Cancer. Breast Cancer Risk Estimation Models. Bioethics
of Genetic Testing for Hereditary Breast Cancer. HBC SYNDROMES WITH KNOWN
GENETIC ETIOLOGIES. Cancer Risks in BRCA1 and BRCA2 Mutation Carriers.
Cowden's Syndrome. Li-Fraumeni Syndrome. Other Syndromes that Include
Breast Cancer as a Component. Low penetrance genes. ASSESSMENT AND
DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS. Biology of
BRCA1/2-associated Carcinogenesis. Genetic Testing and Counseling Issues.
Molecular Diagnostics: Methods and Limitations. Cancer Risk Modifiers.
BRCA1/2 in underserved or special populations. Psychological Impact of
Genetic Testing. SCREENING AND PREVENTION OF HBC. Breast Cancer Screening
and Prevention Options. Ovarian Cancer Screening and Prevention Options.
Management of mutation-negative women. CLINICAL MANAGEMENT OF HBC.
Pathology of Breast Tumors in Hereditary Breast Cancer. Pathology of
Ovarian Tumors in Mutation Carriers. Local treatment Issues in HBC. Breast
Cancer in Mutation Carriers.Impact on Systemic Therapy.