Colm Duffy

Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

• Gebundenes Buch

Produktbeschreibung

This review of the chemistry and biology of stable lipoxin analogues describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4, as well as a route to synthesizing a thiophene-containing LXA4 analogue.

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In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 80114379, 978-3-642-24631-9
• 2012
• Seitenzahl: 152
• Erscheinungstermin: 5. Januar 2012
• Englisch
• Abmessung: 241mm x 160mm x 13mm
• Gewicht: 368g
• ISBN-13: 9783642246319
• ISBN-10: 3642246311
• Artikelnr.: 34009882

Inhaltsangabe

Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.

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Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.