3. 4 Electrocyclic processes in heterocyclic ring synthesis 61 3. 5 Nitrenes in heterocyclic ring synthesis 62 References for chapter 3 63 4 Typical reactivity of pyridines, quinolines and isoquinolines 64 5 Pyridines: reactions and synthesis 72 5. 1 Reactions with electrophilic reagents 73 5. 2 Reactions with oxidising agents 79 5. 3 Reactions with nucleophilic reagents 80 5. 4 Reactions with bases 82 5. 5 Reactions of C-metallated pyridines 83 5. 6 Reactions with radical reagents 85 5. 7 Reactions with reducing agents 86 5. 8 Electrocyclic reactions (ground state) 87 5. 9 Photochemical reactions 88 5. 10 Oxy-and aminopyridines 89 5. 11 Alkylpyridines 94 5. 12 Pyridine aldehydes, ketones, carboxylic acids and esters 95 5. 13 Quatemary pyridinium salts 95 5. 14 Pyridine N -oxides 10 1 5. 15 Synthesis of pyridines 104 References for chapter 5 111 Exercises for chapter 5 118 6 Quinolines and isoquinolines: reactions and synthesis 120 6. 1 Reactions with electrophilic reagents 121 6. 2 Reactions with oxidising agents 123 6. 3 Reactions with nucleophilic reagents 123 6. 4 Reactions with bases 125 6. 5 Reactions of C-metallated quinolines and isoquinolines 126 6. 6 Reactions with radical reagents 126 6. 7 Reactions with reducing agents 126 6. 8 Electrocyclic reactions (ground state) 127 6. 9 Photochemical reactions 128 6. 10 Oxyquinolines and -isoquinolines 128 6. 11 Aminoquinolines and -isoquinolines 130 6. 12 Alkylquinolines and -isoquinolines 130 6.
"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)
"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)
"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)
"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)
"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)
"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)
"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)
"Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry." (Journal of Chemical Education, 1 October 2012)
"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)
"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)
"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)
"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)
"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)
"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)
"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)
"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)