M. Kahn

High Throughput Screening for Novel Anti-Inflammatories

Herausgegeben von Kahn, Michael

• Gebundenes Buch

Produktbeschreibung

Combinatorial chemistry in conjunction with High Throughput Screening
(HTS) is revolutionizing the drug discovery process. Yet, we have much
to learn about the integration of these powerful techniques with
information from genomics, proteomics, computation and pharmacokinetics
before dramatic increases in the drug discovery/development processes
can be achieved. The chapters in this book represent the state of the
art regarding the integration of combinatorial chemistry and HTS in
connection with anti-inflammatory targets. Obviously, there is much work
to be done beyond what is described in this text, nevertheless, it
should set the stage for creative thinking among scientists of many
disciplines for the accomplishment of our ultimate goals in treating
inflammatory diseases.

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Produktdetails

• Progress in Inflammation Research
• Verlag: Birkhäuser Basel / Springer, Basel
• Artikelnr. des Verlages: 10749614
• 2000.
• Seitenzahl: 272
• Erscheinungstermin: 1. Mai 2000
• Englisch
• Abmessung: 241mm x 160mm x 21mm
• Gewicht: 760g
• ISBN-13: 9783764359126
• ISBN-10: 3764359129
• Artikelnr.: 25952939

Inhaltsangabe

Solid phase synthesis: Applications to combinatorial libraries.- Proteasome inhibitors.- Caspase-1 (ICE) and other caspases as drug discovery targets: Opportunities and progress.- Elastase inhibitors.- A high throughput assay for the TNF converting enzyme.- Tryptase inhibitors.- Selectin antagonists.- Cell adhesion integrins as pharmaceutical targets.- Inhibitors of the MAPK pathway.- Inhibition of NF-?B.- IL-1 antagonist discovery.- Phosphodiesterase inhibitors for respiratory diseases.