The methodological strategy addresses how to contribute to the development of the teaching-learning process of the subject History of Cuba in the sixth grade with an interdisciplinary approach. The object of this research is the development of the teaching-learning process of the subject History of Cuba in the sixth grade and the field of research is interdisciplinarity. The proposed objective is to propose a methodological strategy for the development of the teaching-learning process of the subject History of Cuba in the sixth grade with an interdisciplinary approach. The scientific novelty consists in the elaboration of a methodological way for the achievement of the interdisciplinarity of Natural Sciences, Geography and Spanish Language with the teaching-learning process of Cuban History. The methods of the theoretical level that support this research are: historical-logical, analytical-synthetic, inductive-deductive, system approach, transit from the abstract to the concrete and vice versa. The empirical level methods and techniques used were: observation, survey, interview and the experimental method.