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Although HIV-1 has been the most studied infectious agent in the last 30 years and Its widely believed that inducting of neutralizing antibodies were sufficient for the protection against HIV. A novel mode of action of HIV infection assumes that production of neutralizing anti-HIV antibodies is the main cause in enhancing the viral infection and its protection against destruction by the cytotoxic CD8+ T-cells. This postulation differs from the ordinary rationales that depend on the role of neutralizing antibodies in controlling the HIV infection. In this book we introduce ( V20E) as a new therapeutic immune peptides modality with a highly promising cure for HIV-1 disease and human immunodeficiency syndrome.