This research based book is based on the findings of the research work entitled "HIV/AIDS Prevention Education at Mekelle University, such as the current HIV/AIDS prevention policy, the current HIV/AIDS curving practices, ideal HIV/AIDS policy, ideal HIV/AIDS practices, and the inclusion of HIV/AIDS prevention education into the University curriculum, the intentions students have to learning about HIV/AIDS in the curriculum and the psychological factors that are related to this intention. The perception and attitude of university students, instructors, and management bodies at the different levels in the University were assessed via questionnaires, interview checklists, focused group discussions, and documentary review.