HIV/AIDS is a deadly human infective disease. However, currently HIV/AIDS treatment is entering a bottleneck stage (incurable disease treatments). The fundamental issue for HIV/AIDS therapeutics is still unresolved. This book outlines a number of possible pharmaco-therapeutic solutions for scientific investigations, technical advancements and clinical utilities¿including viral origin, biology, pathogenesis, animal model, diagnostics and therapeutics. New viral targets (biotherapy, viral latency and human genomic integration) and long-lasting medical practice (traditional Chinese medicine and new generations of drug combinations and so on) are highlighted.