Robert Lechler / Anthony Warrens (eds.)

HLA in Health and Disease

Herausgeber: Lechler, Robert; Warrens, Anthony

• Gebundenes Buch

Produktbeschreibung

This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry.

Produktdetails

• Verlag: Elsevier Health Sciences
• 2nd edition
• Seitenzahl: 472
• Erscheinungstermin: 9. Mai 2000
• Englisch
• Abmessung: 262mm x 195mm x 26mm
• Gewicht: 1266g
• ISBN-13: 9780124403154
• ISBN-10: 0124403158
• Artikelnr.: 21918852

Inhaltsangabe

Introduction to the HLA System: P. Travers
Structure of Class I and II Molecules. C.M. Milner
R.D. Campbell and J. Trowsdale
Molecular Genetics of the Human MHC. R.J. Baker and A.N. Warrens
The Biology of MHC Molecules. C. AuPeh
A.W. Purcell
and J. McCluskey
The Function of MHC Molecules: Antigen Presentation. T.J. Vyse and B. Morley
The Analysis of Genetic Susceptibility. A. Warrens
Appendix. A. Warrens and R. Lechler
Mechanisms of HLA and Disease Associations. Disease Associations: G.T. Nepom
HLA-Associations with Rheumatoid Arthritis. P. Bowness
HLA and the Spondylarthopathies. R. Phelps and A. Rees
The HLA Complex in Renal Disease. J. Hillert and A. Fogdell-Hahn
HLA Associations in Neurological Diseases. G.T. Nepom
Type 1 Diabetes (IDDM). A.P. Weetman
Endocrinology. L.M. Sollid
A. Spurkland
and E. Thorsby
HLA Associations in Gastrointestinal Diseases. J.S. Pulido and J.W. Steilein
HLA and the Eye. P.A. Glynne and N.M. Price
HLA and Infectious Diseases. M.C. Pickering
M. Perraudeau
and M. Walport
The Systemic Vasculitides
Systemic Lupus Erythematosus
and Sjögren's Syndrome. A. Friedman
Association of the HLA System with Dermatological Diseases. R. Baker and G. Opelz
HLA and Transplantation: Alloimmune Response and the Role of HLA Matching in Clinical Transplantation. P. Wright
V. Nimgaonkar
R. Ganguli
and R. Murray
Psychiatric Disease. Definition of HLA Polymorphism: J.J. van Rood
The History of the Discovery of HLA. P. Dyer
S. Martin
and R. Stanford
Serological Methods in HLA Typing. P. Mason and R. Lechler
Cellular Methods in Testing Histocompatibility. H. Erlich
PCR-Based Methods in HLA Typing. J. Bodmer
W.F. Bodmer
and S. Marsh
HLA Nomenclature: The Name of the Rose. R. Bontrop and J. Kaufman
Evolution of HLA Polymorphisms.