Homology Modeling of Human NK-1 Receptor and Docking Study - Gupta, Manish K.;Kumar, Viney
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Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the…mehr

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Produktbeschreibung
Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provide structural basis for the design of new NK-1 inhibitors and anticancer agents. The authors anticipate that the book will be very useful for the researchers who are working on the design and development of NK-1 receptor antagonists and anticancer agents.
Autorenporträt
Manish Kumar Gupta (M. Pharm., PhD., Postdoc): Professor of Pharmacy, Lloyd Inst. of Mang. & Tech. Gr. Noida, India. His research work focuses on the ligand and structure based drug design, protein modeling and molecular dynamics simulation studies. He has published several research papers in peer-reviewed journals of ACS, Springer and Elsevier.