Hormones, Cognition and Dementia

Herausgeber: Hogervorst, Eef

• Gebundenes Buch

Produktbeschreibung

Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.

Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 296
• Erscheinungstermin: 24. September 2009
• Englisch
• Abmessung: 260mm x 208mm x 21mm
• Gewicht: 864g
• ISBN-13: 9780521899376
• ISBN-10: 0521899370
• Artikelnr.: 26565342

Inhaltsangabe

Preface; Part I. Estrogens and Cognition: 1. Women's Health Initiative
Memory Study (WHIMS) program; 2. Identifying risk-factors for cognitive
change in the Women's Health Initiative; 3. Estrogen therapy ¿ relationship
to longevity and prevalent dementia in the oldest-old; 4. The critical
window hypothesis: hormone exposures and cognitive outcomes after
menopause; 5. Animal studies that support estrogen effects on cognitive
performance and the cholinergic basis of the critical period hypothesis;
Part II. Varieties of Estrogenic Therapy: 6. The healthy cell bias of
estrogen action through regulating glucose metabolism and mitochondrial
function; 7. Alternative estrogenic treatment regimes and the Kronos Early
Estrogen Prevention Study-Cognitive and Affective Substudy (KEEPS-CA); 8.
The use of transdermal 17-estradiol in the treatment of Alzheimer's
disease; 9. Alternative modes of treatment: pulsatile estradiol treatment;
10. In search of estrogen alternatives for the brain; Part III. Potential
Modulators and Modifiers of Estrogenic Effects: 11. Progesterone regulation
of neuroprotective estrogen actions; 12. Clinical data of estrogen's
effects in the central nervous system; 13. Different forms of soy
processing may determine the positive or negative impact on cognitive
function of Indonesian elderly; 14. Hypothalamus-pituitary-adrenal axis
activity in aging women; Part IV. Possible Genetic Factors Related to
Hormone Treatment Effects: 15. Possible genetic polymorphisms related to
sex steroid metabolism and dementia in women; 16. Genetics related to sex
steroids: implications for Alzheimer's disease; 17. Apolipoprotein E,
hormone therapy and neuroprotection; 18. Testosterone, gonadotrophins and
genetic polymorphisms in men with Alzheimer's disease; Part V.
Testosterone, Estradiol and Men, and Sex Hormone Binding Globulin: 19.
Androgens and cognitive functioning in women; 20. The role of estradiol in
testosterone treatment; 21. Endogenous testosterone levels and cognitive
aging in men; 22. Clinical trials and neuroimaging studies of testosterone
in men: insights into effects on verbal memory; 23. Testosterone therapy
and Alzheimer's disease: potential for treatment and prevention in women;
24. Endogenous estradiol and dementia in elderly men: the roles of vascular
risk, sex hormone binding globulin, and aromatase activity; 25.
Testosterone regulates Alzheimer's disease pathogenesis; Part VI.
Gonadotropin Effects: 26. Involvement of gonadotropins in cognitive
function: implications for Alzheimer's disease; 27. The role of
gonadotropins and testosterone in the regulation of beta amyloid
metabolism; 28. Epilogue; 29. Concluding remarks; Index.